ACOMPARATIVE STUDY OF FLUMAZENIL VERSUS AMINOPHYLLINE ON LEVEL OF CONSCIOUSNESS AND NEUROMOTOR STATUS AFTER ISOFLURANE ANESTHESIA

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PARVIZ KAZEMI ASEF; AMINI AFSHIN; DEHGHANPISHEH LALEH

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Journal: JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE Year:2012 | Volume:34 | Issue:79 Page(s): 15-20

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Title

ACOMPARATIVE STUDY OF FLUMAZENIL VERSUS AMINOPHYLLINE ON LEVEL OF CONSCIOUSNESS AND NEUROMOTOR STATUS AFTER ISOFLURANE ANESTHESIA

Author(s)

PARVIZ KAZEMI ASEF | AMINI AFSHIN | DEHGHANPISHEH LALEH | Issue Writer Certificate

Keywords

FLUMAZENILQ3

AMINOPHYLLINEQ2

ISOFLURANE ANESTHESIAQ2

VIGILANCEQ2

NEUROMOTOR FUNCTIONSQ2

Abstract

Introduction: Recovery from anesthesia induced with inhalation agents can be distressing because of prolonged mental function deficiency, disorientation and abnormal neurological reflexes. So we designed this study to compare the effect of FLUMAZENIL versus AMINOPHYLLINE on cognitive and neuromotor status after ISOFLURANE ANESTHESIA.Materials and methods: To conduct this randomized, placebo-controlled, double-blinded study, 90 ASAI-II patients who underwent orthopedic surgery under N2O/O2 plus ISOFLURANE ANESTHESIA were administered FLUMAZENIL 1mg, AMINOPHYLLINE 2mg/Kg or placebo upon emergence from anesthesia, and their VIGILANCE and neurological recovery were assessed.Results: Comparison of three groups in VIGILANCE score showed significant statistical difference at minute 5, 10, 20. (p<0.001, p=0.016). Recovery of VIGILANCE in FLUMAZENIL treated patients compared to those who received AMINOPHYLLINE was faster at minutes of 5, 10 and 20 (p=0.001, p=0.001, p=0.038) and in AMINOPHYLLINE treated patients compared to placebo group was better at 5, 10, 20 and 30 minutes (p<0.001, p=0.1001, p=0.008 and p=0.04).Neurological score between there groups at 5, 10, 20, 30 minutes has signification statistical difference (p<0.001, p<0.001, p=0.001 and p=0.048). Neurological score showed better recovery of FLUMAZENIL treated patients compared to AMINOPHYLLINE treated patients at minutes 5 and 10 (p=0.001, p=0.005). Neurologic recovery in aminophyllne group was faster than placebo group at minute 5, 10 and 20 (p=0.028, p=0.001, and p=0.013).Conclusion: This study showed that bolk FLUMAZENIL and amynophyline are effective in improving recovery of VIGILANCE and NEUROMOTOR FUNCTIONS following ISOFLURANE ANESTHESIA, but FLUMAZENIL proved to be more effective.

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APA: Copy

PARVIZ KAZEMI, ASEF, AMINI, AFSHIN, & DEHGHANPISHEH, LALEH. (2012). ACOMPARATIVE STUDY OF FLUMAZENIL VERSUS AMINOPHYLLINE ON LEVEL OF CONSCIOUSNESS AND NEUROMOTOR STATUS AFTER ISOFLURANE ANESTHESIA. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, 34(79), 15-20. SID. https://sid.ir/paper/63204/en

Vancouver: Copy

PARVIZ KAZEMI ASEF, AMINI AFSHIN, DEHGHANPISHEH LALEH. ACOMPARATIVE STUDY OF FLUMAZENIL VERSUS AMINOPHYLLINE ON LEVEL OF CONSCIOUSNESS AND NEUROMOTOR STATUS AFTER ISOFLURANE ANESTHESIA. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE[Internet]. 2012;34(79):15-20. Available from: https://sid.ir/paper/63204/en

IEEE: Copy

ASEF PARVIZ KAZEMI, AFSHIN AMINI, and LALEH DEHGHANPISHEH, “ACOMPARATIVE STUDY OF FLUMAZENIL VERSUS AMINOPHYLLINE ON LEVEL OF CONSCIOUSNESS AND NEUROMOTOR STATUS AFTER ISOFLURANE ANESTHESIA,” JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, vol. 34, no. 79, pp. 15–20, 2012, [Online]. Available: https://sid.ir/paper/63204/en

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