A COMPARISON OF THE EFFECT OF TWO PREMEDITATIONS, MIDAZOLAM AND DIAZEPAM ON POSTOPERATIVE COGNITIVE DYSFUNCTION IN PATIENTS OVER 60 YEARS OLD AFTER SURGERY WITH GENERAL ANESTHESIA

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

TAVAKOLIAN A.R.; FARBOUD A.; MASJEDY M.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE Year:2003 | Volume:22 | Issue:40 Page(s): 33-42

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

1,357

Download:

Cites:

Information Journal Paper

Title

A COMPARISON OF THE EFFECT OF TWO PREMEDITATIONS, MIDAZOLAM AND DIAZEPAM ON POSTOPERATIVE COGNITIVE DYSFUNCTION IN PATIENTS OVER 60 YEARS OLD AFTER SURGERY WITH GENERAL ANESTHESIA

Author(s)

TAVAKOLIAN A.R. | FARBOUD A. | MASJEDY M. | Issue Writer Certificate

Keywords

GENERAL ANESTHESIAQ3

COGNITIVE DYSFUCTIONQ4

ELDERLYQ4

DIAZEPAMQ3

MIDAZOLAMQ3

Abstract

Postoperative cognitive dysfunction is a significant problem in ELDERLY patients. Among proposed causes is used of tranquilizers including benzodiazepines. Related studies have different and occasionally opposite results.We decided to evaluate and compare the postoperative cognitive dysfunction in ELDERLY patients after receiving midazolan and DIAZEPAM as premeditation.We studied 120 ASA physical status I-II ELDERLY patients (>60yrs old) undergoing surgery with GENERAL ANESTHESIA, that they were randomly assigned to one of three groups (each group 40 patients). Patients who were illiterates, opium addicts, patients with psychologic problem, patients who had used any tranquilizer (even as a single dose on the evening prior to operation) and who had neurosurgical or open heart surgery. Patients in the first group (control) did not receive any benzodiazepine for premeditation while DIAZEPAM (0.1mg/kg) and MIDAZOLAM (0.03mg/ kg) were given intravenously to the second and third group. In addition morphine (0.1mg/kg) administered to all patients.Anesthesia was induced with hypnotic doses of thiopental and trachea was intubated by the aid of atracurium (0.5mg/kg).Anesthesia was maintained with halothane (0.5-0.75%) in combination with nitrous oxide 50% in oxygen.To asses cognitive function, the Mini-Mental State (MMS) test was used half an hour preoperatively and 4 hours postoperatively.The means scores calculated and compared in the groups. In the three groups means of MMS scores were reduced postoperative from preoperative scores. Patients in the control group showed 1.12, in DIAZEPAM group 1.72 and in MIDAZOLAM group 1.35 decline in means of MMS scores. Besides, because reduction of two or more scores in MMS test was accepted as cognitive dysfunction, 11 patients (27.5%) in control group, 25 patients (62.5%) in DIAZEPAM group and 17 patients (42.5%) in MIDAZOLAM group had postoperative cognitive dysfunction (p value< 0.05).We concluded that both MIDAZOLAM and DIAZEPAM cause significant reduction in early postoperative cognitive function of the ELDERLY and this was more prominent with DIAZEPAM.

Cites

No record.

References

No record.

Cite

APA: Copy

TAVAKOLIAN, A.R., FARBOUD, A., & MASJEDY, M.. (2003). A COMPARISON OF THE EFFECT OF TWO PREMEDITATIONS, MIDAZOLAM AND DIAZEPAM ON POSTOPERATIVE COGNITIVE DYSFUNCTION IN PATIENTS OVER 60 YEARS OLD AFTER SURGERY WITH GENERAL ANESTHESIA. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, 22(40), 33-42. SID. https://sid.ir/paper/63222/en

Vancouver: Copy

TAVAKOLIAN A.R., FARBOUD A., MASJEDY M.. A COMPARISON OF THE EFFECT OF TWO PREMEDITATIONS, MIDAZOLAM AND DIAZEPAM ON POSTOPERATIVE COGNITIVE DYSFUNCTION IN PATIENTS OVER 60 YEARS OLD AFTER SURGERY WITH GENERAL ANESTHESIA. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE[Internet]. 2003;22(40):33-42. Available from: https://sid.ir/paper/63222/en

IEEE: Copy

A.R. TAVAKOLIAN, A. FARBOUD, and M. MASJEDY, “A COMPARISON OF THE EFFECT OF TWO PREMEDITATIONS, MIDAZOLAM AND DIAZEPAM ON POSTOPERATIVE COGNITIVE DYSFUNCTION IN PATIENTS OVER 60 YEARS OLD AFTER SURGERY WITH GENERAL ANESTHESIA,” JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, vol. 22, no. 40, pp. 33–42, 2003, [Online]. Available: https://sid.ir/paper/63222/en

Related Journal Papers