PULMONARY EFFECTS OF N-ACETYLCYSTEINE IN PATIENTS UNDERGOIQG CORONARY ARTERY BYPASS SURGERY WITH CARDIOPULMONARY BYPASS

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AGHA DAVOUDI O.; MOHAMMAD ALI BEYGI R.

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Journal: JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE Year:2006 | Volume:28 | Issue:54 Page(s): 4-14

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Title

PULMONARY EFFECTS OF N-ACETYLCYSTEINE IN PATIENTS UNDERGOIQG CORONARY ARTERY BYPASS SURGERY WITH CARDIOPULMONARY BYPASS

Author(s)

AGHA DAVOUDI O. | MOHAMMAD ALI BEYGI R. | Issue Writer Certificate

Keywords

CARDIAC SURGERY. CARDIOPULMONARY BYPASSQ3

N-ACETYLCYSTEINE. PULMONARY EFFECTSQ3

Abstract

Background: Cardiac surgery and cardiopulmonary bypass (CPB) initiate a systemic inflammatory response which adversely affects postoperative pulmonary function. The purpose of the present study was to assess the pulmonary effects of N-acetylcysteine (NAC) in patients undergoing Coronary artery bypass graft surgery (CABG) Materials and methods: In a randomized. Double blind, clinical trial study (April-October 2005) in our institution, forty consenting patients undergoing elective CABG were randomized into two groups. Group I (20 patients) received a physiologic saline solution as a placebo one hour before CPB; group II (20 patients) received 50 mg/kg NAC intravenously for one hour before CPB. Preoperative hemodynamic and pulmonary data were recorded. Data were analyzed by SPSS 11.5 software using appropriate tests including Chi-square and T-tests. The results were evaluated as the mean±SE and considered statistically significant for p<0.05.Results: The preoperative demographic and basic clinical variables including mean age (59.1+1.4). Body mass index (25.7±0.6), cardiac ejection fraction (47.1±1.7), and pulmonary function test (PFT) and CPB time (109.2±4.7) were similar in the two groups.Patients in group I exhibited significantly lower dynamic lung compliances in the ICU (p<0.05). The rapid shallow breathing index (RSBI) was significantly more in group I (p<0.001).The static lung compliance was better in group II (p<0.001). There was no significant difference in terms of mechanical ventilation duration, intubation time and ICU stay.Conclusion: This clinical study reveals that administration of NAC to patients undergoing elective CABG with CPB improves some pulmonary parameters in the postoperative period but does not alter the duration of mechanical ventilation and ICU stay. So we believe that the effect of NAC in the pulmonary function after CPB needs to be further evaluated.

Cites

EFFECTIVENESS OF ORAL N-ACETYL-CYSTEIN IN REDUCTION OF PULMONARY COMPLICATIONS IN SMOKERS UNDERGOING CORONARY ARTERY BYPASS SURGERY

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APA: Copy

AGHA DAVOUDI, O., & MOHAMMAD ALI BEYGI, R.. (2006). PULMONARY EFFECTS OF N-ACETYLCYSTEINE IN PATIENTS UNDERGOIQG CORONARY ARTERY BYPASS SURGERY WITH CARDIOPULMONARY BYPASS. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, 28(54), 4-14. SID. https://sid.ir/paper/63272/en

Vancouver: Copy

AGHA DAVOUDI O., MOHAMMAD ALI BEYGI R.. PULMONARY EFFECTS OF N-ACETYLCYSTEINE IN PATIENTS UNDERGOIQG CORONARY ARTERY BYPASS SURGERY WITH CARDIOPULMONARY BYPASS. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE[Internet]. 2006;28(54):4-14. Available from: https://sid.ir/paper/63272/en

IEEE: Copy

O. AGHA DAVOUDI, and R. MOHAMMAD ALI BEYGI, “PULMONARY EFFECTS OF N-ACETYLCYSTEINE IN PATIENTS UNDERGOIQG CORONARY ARTERY BYPASS SURGERY WITH CARDIOPULMONARY BYPASS,” JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, vol. 28, no. 54, pp. 4–14, 2006, [Online]. Available: https://sid.ir/paper/63272/en

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