PROPHYLACTIC EFFECTS OF I.V. DEXAMETHASONE VS. METOCLOPRAMIDE IN PREVENTING NAUSEA AND VOMITING DURING INTRATHECAL INJECTION OF MEPERIDINE

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MOAFEGH A.; HOSSEI NKHAN Z.; HOJAT M.

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Journal: JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE Year:2004 | Volume:25 | Issue:45 Page(s): 47-56

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Title

PROPHYLACTIC EFFECTS OF I.V. DEXAMETHASONE VS. METOCLOPRAMIDE IN PREVENTING NAUSEA AND VOMITING DURING INTRATHECAL INJECTION OF MEPERIDINE

Author(s)

MOAFEGH A. | HOSSEI NKHAN Z. | HOJAT M. | Issue Writer Certificate

Keywords

DEXAMETHASONEQ2

NAUSEAQ2

VOMITINGQ3

Abstract

To determine and compare the prophylactic effects of i.v. DEXAMETHASONE 8mg with metoclopramide in preventing NAUSEA and VOMITING during intrathecal injection of meperidine for postoperative analgesia.In a randomized, double-blinded, placebo-controlled study, 105 ASA physical status I or II men ranging 18-40 years underwent elective lower limb orthopedic surgery receiving spinal anesthesia with 75mg lidocaine 5% and 15mg meperidine for postoperative analgesia, were enrolled. Patients were randomly allocated to normal saline (2ml saline, iv), methoc1opramide (2ml equal to 10mg, iv) and DEXAMETHASONE (2ml equal to 8mg DEXAMETHASONE, iv) groups and received their medications just before surgery. The incidence of PONV and side effects were evaluated during surgery, recovery period, 6 and 24hr after spinal anesthesia.The differences between demographic and hemodynamic variables, infused ringer duration of surgery, highest level of anesthesia, and number of patients requiring rescue antiemetics and analgesics and postoperative pain intensity were not significant. Patients who received dexmethasone and metoc1opramide, have significantly lower incidence of NAUSEA and VOMITING compared who received saline in recovery period, 6 and 24hr after spinal anesthesia (p<0.05). The incidence of NAUSEA in 6 and 24 hr and the incidence of VOMITING in 24hr after spinal anesthesia were significantly lower in DEXAMETHASONE compared with metoc1opramide (p<0.05).DEXAMETHASONE, 8mg i.v., is suggested in preventing NAUSEA and VOMITING associated with intrathecal injection of meperidine for postoperative analgesia.

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APA: Copy

MOAFEGH, A., HOSSEI NKHAN, Z., & HOJAT, M.. (2004). PROPHYLACTIC EFFECTS OF I.V. DEXAMETHASONE VS. METOCLOPRAMIDE IN PREVENTING NAUSEA AND VOMITING DURING INTRATHECAL INJECTION OF MEPERIDINE. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, 25(45), 47-56. SID. https://sid.ir/paper/63274/en

Vancouver: Copy

MOAFEGH A., HOSSEI NKHAN Z., HOJAT M.. PROPHYLACTIC EFFECTS OF I.V. DEXAMETHASONE VS. METOCLOPRAMIDE IN PREVENTING NAUSEA AND VOMITING DURING INTRATHECAL INJECTION OF MEPERIDINE. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE[Internet]. 2004;25(45):47-56. Available from: https://sid.ir/paper/63274/en

IEEE: Copy

A. MOAFEGH, Z. HOSSEI NKHAN, and M. HOJAT, “PROPHYLACTIC EFFECTS OF I.V. DEXAMETHASONE VS. METOCLOPRAMIDE IN PREVENTING NAUSEA AND VOMITING DURING INTRATHECAL INJECTION OF MEPERIDINE,” JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, vol. 25, no. 45, pp. 47–56, 2004, [Online]. Available: https://sid.ir/paper/63274/en

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