MODULATING EFFECTS OF SPIRULINA PLATENSIS AGAINST TILMICOSIN-INDUCED CARDIOTOXICITY IN MICE

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E.IBRAHIM ABDELAZIZ; MOHAMED ABDEL DAIM MOHAMED

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Journal Paper

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Journal: Cell Journal (Yakhteh) Year:2015 | Volume:17 | Issue:1 (65) Page(s): 137-144

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Title

MODULATING EFFECTS OF SPIRULINA PLATENSIS AGAINST TILMICOSIN-INDUCED CARDIOTOXICITY IN MICE

Author(s)

E.IBRAHIM ABDELAZIZ | MOHAMED ABDEL DAIM MOHAMED | Issue Writer Certificate

Keywords

TILMICOSIN

OXIDATIVE STRESS

SPIRULINA

ANTIOXIDANT

HEART

Abstract

Objective: TILMICOSIN (TIL) is a long-acting macrolide antibiotic used to treat cattle for pathogens that cause bovine respiratory disease. However, overdoses of this medication have been reported to induce cardiac damage. Our experimental objective was to evaluate the protective effects of SPIRULINA platensis (SP) administration against TIL-induced cardiotoxicity in mice.Materials and Methods: Our experimental in vivo animal study used 40 male albino mice that were divided into five groups of eight mice per group. The first group served as a control group and was injected with saline. The second group received SP at dose of 1000 mg/kg body weight for five days. The third group received a single dose of TIL (75 mg/kg, subcutaneously). Groups 4 and 5 were given SP at doses of 500 and 1000 mg/kg body weight for five consecutive days just before administration of TIL at the same dose and regimen used for group 3.Results: TIL treated animals showed a significant increase in serum cardiac injury biomarkers as well as cardiac lipid peroxidation, however they had evidence of an inhibition in ANTIOXIDANT biomarkers. SP normalized elevated serum levels of lactate dehydrogenase (LDH), creatine kinase (CK), and CK-MB. Furthermore, SP reduced TIL-induced lipid peroxidation and OXIDATIVE STRESS in a dose-dependent manner.Conclusion: Administration of SP minimized the toxic effects of TIL by its free radicalscavenging and potent ANTIOXIDANT activity.

Cites

EFFECTS OF NIGELLA SATIVA OIL AND ASCORBIC ACID AGAINST OXYTETRACYCLINE-INDUCED HEPATO-RENAL TOXICITY IN RABBITS

References

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APA: Copy

E.IBRAHIM, ABDELAZIZ, & MOHAMED ABDEL DAIM, MOHAMED. (2015). MODULATING EFFECTS OF SPIRULINA PLATENSIS AGAINST TILMICOSIN-INDUCED CARDIOTOXICITY IN MICE. CELL JOURNAL (YAKHTEH), 17(1 (65)), 137-144. SID. https://sid.ir/paper/632912/en

Vancouver: Copy

E.IBRAHIM ABDELAZIZ, MOHAMED ABDEL DAIM MOHAMED. MODULATING EFFECTS OF SPIRULINA PLATENSIS AGAINST TILMICOSIN-INDUCED CARDIOTOXICITY IN MICE. CELL JOURNAL (YAKHTEH)[Internet]. 2015;17(1 (65)):137-144. Available from: https://sid.ir/paper/632912/en

IEEE: Copy

ABDELAZIZ E.IBRAHIM, and MOHAMED MOHAMED ABDEL DAIM, “MODULATING EFFECTS OF SPIRULINA PLATENSIS AGAINST TILMICOSIN-INDUCED CARDIOTOXICITY IN MICE,” CELL JOURNAL (YAKHTEH), vol. 17, no. 1 (65), pp. 137–144, 2015, [Online]. Available: https://sid.ir/paper/632912/en

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