EVALUATION OF THE COMBINED EFFECTS OF HYPERTHERMIA, COBALT-60 GAMMA RAYS AND IUDR ON CULTURED GLIOBLASTOMA SPHEROID CELLS AND DOSIMETRY USING TLD-100

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

NESHASTEH RIZ ALI; RAHDANI ROZHIN; MOSTAAR AHMAD

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Cell Journal (Yakhteh) Year:2014 | Volume:16 | Issue:3 (63) Page(s): 335-342

Download Full-Text

View:

323

Download:

193

Cites:

Information Journal Paper

Title

EVALUATION OF THE COMBINED EFFECTS OF HYPERTHERMIA, COBALT-60 GAMMA RAYS AND IUDR ON CULTURED GLIOBLASTOMA SPHEROID CELLS AND DOSIMETRY USING TLD-100

Author(s)

NESHASTEH RIZ ALI | RAHDANI ROZHIN | MOSTAAR AHMAD | Issue Writer Certificate

Keywords

RADIATION

HYPERTHERMIA

IUDR

GLIOBLASTOMA

COMET ASSAY

Abstract

Objective: In RADIATION treatment, the irRADIATION which is effective enough to control the tumors far exceeds normal-tissues tolerance. Thus to avoid such unfavourable outcomes, some methods sensitizing the tumor cells to RADIATION are used. Iododeoxyuridine (IUdR) is a halogenated thymidine analogue that known to be effective as a radiosensitizer in human cancer therapy. Improving the potential efficacy of RADIATION therapy after combining to HYPERTHERMIA depends on the magnitude of the differential sensitization of the hyperthermic effects or on the differential cytotoxicity of the RADIATION effects on the tumor cells. In this study, we evaluated the combined effects of IUDR, HYPERTHERMIA and gamma rays of 60Co on human GLIOBLASTOMA spheroids culture.Materials and Methods: In this experimental study, the cultured spheroids with 100mm diameter were treated by 1mM IUDR, 43o HYPERTHERMIA for an hour and 2 Gy gamma rays, respectively. The DNA damages induced in cells were compared using alkaline COMET ASSAY method, and dosimetry was then performed by TLD-100. Comet scores were calculated as mean±standard error of mean (SEM) using one-way ANOVA.Results: Comparison of DNA damages induced by IUDR and HYPERTHERMIA+gamma treatment showed 2.67- and 1.92-fold enhancement, respectively, as compared to the damages induced by RADIATION alone or RADIATION combined IUDR. Dosimetry results showed the accurate dose delivered to cells.Conclusion: Analysis of the comet tail moments of spheroids showed that the RADIATION treatments combined with HYPERTHERMIA and IUDR caused significant radiosensitization when compared to related results of irRADIATION alone or of irRADIATION with IUDR. These results suggest a potential clinical advantage of combining RADIATION with HYPERTHERMIA and indicate effectiveness of HYPERTHERMIA treatment in inducing cytotoxicity of tumor cells.

Cites

No record.

References

Cite

APA: Copy

NESHASTEH RIZ, ALI, RAHDANI, ROZHIN, & MOSTAAR, AHMAD. (2014). EVALUATION OF THE COMBINED EFFECTS OF HYPERTHERMIA, COBALT-60 GAMMA RAYS AND IUDR ON CULTURED GLIOBLASTOMA SPHEROID CELLS AND DOSIMETRY USING TLD-100. CELL JOURNAL (YAKHTEH), 16(3 (63)), 335-342. SID. https://sid.ir/paper/633067/en

Vancouver: Copy

NESHASTEH RIZ ALI, RAHDANI ROZHIN, MOSTAAR AHMAD. EVALUATION OF THE COMBINED EFFECTS OF HYPERTHERMIA, COBALT-60 GAMMA RAYS AND IUDR ON CULTURED GLIOBLASTOMA SPHEROID CELLS AND DOSIMETRY USING TLD-100. CELL JOURNAL (YAKHTEH)[Internet]. 2014;16(3 (63)):335-342. Available from: https://sid.ir/paper/633067/en

IEEE: Copy

ALI NESHASTEH RIZ, ROZHIN RAHDANI, and AHMAD MOSTAAR, “EVALUATION OF THE COMBINED EFFECTS OF HYPERTHERMIA, COBALT-60 GAMMA RAYS AND IUDR ON CULTURED GLIOBLASTOMA SPHEROID CELLS AND DOSIMETRY USING TLD-100,” CELL JOURNAL (YAKHTEH), vol. 16, no. 3 (63), pp. 335–342, 2014, [Online]. Available: https://sid.ir/paper/633067/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops