COMPARISON OF THE PREVENTIVE EFFECT OF ORAL SUCRALFATE AND INTRAVENOUS RANITIDINE ON STRESS ULCER, GASTRIC ACIDITY AND THE INCIDENCE OF PNEUMONIA IN CRITICALLY ILL PATIENTS

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SOLTANINEZHAD H.A.; HASHEMI SEYED JALAL; TALAKOUB R.; SAGHAEI M.

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Paper Information

Journal: JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE Year:2006 | Volume:28 | Issue:53 Page(s): 4-13

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Title

COMPARISON OF THE PREVENTIVE EFFECT OF ORAL SUCRALFATE AND INTRAVENOUS RANITIDINE ON STRESS ULCER, GASTRIC ACIDITY AND THE INCIDENCE OF PNEUMONIA IN CRITICALLY ILL PATIENTS

Author(s)

SOLTANINEZHAD H.A. | HASHEMI SEYED JALAL | TALAKOUB R. | SAGHAEI M. | Issue Writer Certificate

Keywords

STRESS ULCERQ3

SUCRALFATEQ4

RANITIDINEQ3

GASTRIC PHQ3

CONTAMINATIONQ2

LUNG INFECTIONQ3

Abstract

Background: There are some controversies in methods of STRESS ULCER prophylaxis in critically ill patients. The aim of this study was to compare the efficacy of RANITIDINE and SUCRALFATE on STRESS ULCER prophylaxis, gastric acidity and CONTAMINATION and development of LUNG INFECTION in critically ill patients under mechanical ventilation.Material and Methods: In this clinical trial, 44 patients were randomly divided in two groups and received RANITIDINE or SUCRALFATE for STRESS ULCER prophylaxis. The occurrence of STRESS ULCER, LUNG INFECTION, positive culture and pH of gastric secretions were determined in both groups. Statistical anlaysis was performed using X2 and T-tests.Results: There was no statistical difference between two groups as far as demographic data and the reasons of STRESS ULCER prophylaxis was concerned. The frequency of STRESS ULCER in RANITIDINE and SUCRALFATE groups was 7.4% vs. 17.6%, LUNG INFECTION was 14.8% vs. 17.6%, positive gastric secretion culture was 59.3% vs. 47.1%and the mean of GASTRIC PH was 4.3±1.4 vs. 3.9±1.1 respectively. Positive fungal culture of gastric secretions was significantly greater in RANITIDINE than SUCRALFATE group (48% vs. 11%. p=0.01).Conclusion: In some studies, the preference of SUCRALFATE to RANITIDINE has been advocated for STRESS ULCER prophylaxis. In present study the frequency of positive fungal culture of gastric secretions was lower in SUCRALFATE than RANITIDINE group.

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APA: Copy

SOLTANINEZHAD, H.A., HASHEMI, SEYED JALAL, TALAKOUB, R., & SAGHAEI, M.. (2006). COMPARISON OF THE PREVENTIVE EFFECT OF ORAL SUCRALFATE AND INTRAVENOUS RANITIDINE ON STRESS ULCER, GASTRIC ACIDITY AND THE INCIDENCE OF PNEUMONIA IN CRITICALLY ILL PATIENTS. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, 28(53), 4-13. SID. https://sid.ir/paper/63369/en

Vancouver: Copy

SOLTANINEZHAD H.A., HASHEMI SEYED JALAL, TALAKOUB R., SAGHAEI M.. COMPARISON OF THE PREVENTIVE EFFECT OF ORAL SUCRALFATE AND INTRAVENOUS RANITIDINE ON STRESS ULCER, GASTRIC ACIDITY AND THE INCIDENCE OF PNEUMONIA IN CRITICALLY ILL PATIENTS. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE[Internet]. 2006;28(53):4-13. Available from: https://sid.ir/paper/63369/en

IEEE: Copy

H.A. SOLTANINEZHAD, SEYED JALAL HASHEMI, R. TALAKOUB, and M. SAGHAEI, “COMPARISON OF THE PREVENTIVE EFFECT OF ORAL SUCRALFATE AND INTRAVENOUS RANITIDINE ON STRESS ULCER, GASTRIC ACIDITY AND THE INCIDENCE OF PNEUMONIA IN CRITICALLY ILL PATIENTS,” JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, vol. 28, no. 53, pp. 4–13, 2006, [Online]. Available: https://sid.ir/paper/63369/en

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