EFFECT OF SMALL DOSES OF SUCCINYLCHOLINE ON TRACHEAL INTUBATION CONDITIONS

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ATASHKHOUEI S.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Paper Information

Journal: JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE Year:2006 | Volume:27 | Issue:51 Page(s): 42-49

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Title

EFFECT OF SMALL DOSES OF SUCCINYLCHOLINE ON TRACHEAL INTUBATION CONDITIONS

Author(s)

ATASHKHOUEI S. | Issue Writer Certificate

Keywords

NEUROMUSCULAR BLOCKQ3

SUCCINYLCHOLINEQ3

TRACHEAL INTUBATIONQ3

COMPLICATIONSQ3

Abstract

Background: SUCCINYLCHOLINE 1mg/kg usually produces excellent TRACHEAL INTUBATION in 60sec. Recovery of respiratory muscle function after this dose however, is not fast enough to forestall oxyhemoglobin desaturatlon when ventilation can not be assisted. In this study, smaller doses of SUCCINYLCHOLINE effects were Investigated for producing satisfactory intubation conditions fast enough to allow rapid sequence TRACHEAL INTUBATION with shorter recovery time of respiratory fuction. Materials and Methods: In this prospective, randomized, and double-blind study, 120 patients, Class I or II of ASA was investigated. After induction of anesthesia with fentanyl - thiopental, all patients were randomly allocated to three groups according to the dose of SUCCINYLCHOLINE 0.3mg/kg (1×ED95), 0.6 mg/kg (2×ED95), and 1mg/kg (3×ED95). Evoked adductor policicis responses to Train-of-four (TOF) in ulnar nerve stimulation were rewarded using nerve stimulator. Onset time, maximal twitch depression, intensity of fasciculation, TRACHEAL INTUBATION conditions, respiration recovery time (apnea time), time to 90% twitch height recovery. and incidence of postoperative myalgia were recorded. Results: Onset times ranged between 81sec and 49sec, decreasing with increasing doses of SUCCINYLCHOLINE but not differing between 0.6 and 1 mg/kg. Maximum twitch depression was similar after 0.6 and 1mg/kg (98.2% - 100%). Intensity of fasciculation was significantly lower in smaller doses. Intubation conditions were often unacceptable after 0.3 mg/kg dose, but acceptable intubations were achieved in all patients receiving a 0.6 and 1mg/kg dose of SUCCINYLCHOLINE. Time to respiration function recovery was significantly shorter in the 0.3 and 0.6mg/kg doses (mean 1.8 and 2.4 min. respectively) versus patients receiving 1mg/kg (mean 6.3 min). Twitch recovery time to T1 = 90% (regular spontaneous respiration) were significantly lower in 0.6 mg/kg dose than 1.0 mg/kg group. Incidence of postoperative myalgia was significantly lower in smaller doses versus patients receiving1mg/kg. Conclusion: The use of 0.6mg/kg of SUCCINYLCHOLINE can produce acceptable intubation conditions 60sec after administration. The conditions achieved after 0.6 mg/kg are similar to those after 1mg/kg. These smaller doses are associated with shorter apnea time, faster twitch recovery, and lower myalgia.

Cites

EFFECT OF SMALL-DOSE OF EPHEDRINE ADMINISTERED PRIOR TO INDUCTION OF ANESTHESIA ON THE ONSET TIME OF SUCCINYLCHOLINE

References

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APA: Copy

ATASHKHOUEI, S.. (2006). EFFECT OF SMALL DOSES OF SUCCINYLCHOLINE ON TRACHEAL INTUBATION CONDITIONS. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, 27(51), 42-49. SID. https://sid.ir/paper/63455/en

Vancouver: Copy

ATASHKHOUEI S.. EFFECT OF SMALL DOSES OF SUCCINYLCHOLINE ON TRACHEAL INTUBATION CONDITIONS. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE[Internet]. 2006;27(51):42-49. Available from: https://sid.ir/paper/63455/en

IEEE: Copy

S. ATASHKHOUEI, “EFFECT OF SMALL DOSES OF SUCCINYLCHOLINE ON TRACHEAL INTUBATION CONDITIONS,” JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, vol. 27, no. 51, pp. 42–49, 2006, [Online]. Available: https://sid.ir/paper/63455/en

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