STUDYING THE RELATIONSHIP BETWEEN POLYMORPHISMS - 2518A/GMCP-1 GENE WITH BEHCET’S DISEASE IN THE POPULATION OF THE NORTH WEST OF IRAN

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GHAFFARI LALEH MARYAM; JABBARPOUR BONYADI MORTEZA; JABBARPOUR BONYADI MOHAMMAD HOSEIN

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Journal: Studies in Medical Sciences Year:2017 | Volume:28 | Issue:6 Page(s): 418-424

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Title

STUDYING THE RELATIONSHIP BETWEEN POLYMORPHISMS - 2518A/GMCP-1 GENE WITH BEHCET’S DISEASE IN THE POPULATION OF THE NORTH WEST OF IRAN

Author(s)

GHAFFARI LALEH MARYAM | JABBARPOUR BONYADI MORTEZA | JABBARPOUR BONYADI MOHAMMAD HOSEIN | Issue Writer Certificate

Keywords

BEHCET’S DISEASEQ2

POLYMORPHISMQ1

MCP-1 GENEQ2

PCR-RFLPQ3

Abstract

Background & Aims: BEHCET’S DISEASE (BD) is an inflammatory vasculitis of unclear etiology. MCP-1 GENE is a member of the C-C chemokines family that is a chemotactic factor for monocytes. The results obtained have shown that the -2518A/G POLYMORPHISM ofMCP-1 gene is associated with BD. The aim of this study was to evaluate the possible involvement of this POLYMORPHISM and BEHCET’S DISEASE in the population of the North West of Iran.Materials & Methods: A case-control association study was performed on 72 BD patients and 78 geographically healthy controls using PCR-RFLP. The results were analyzed with chi-square and Fisher exact test.Results: Statistical analysis did not show a significant relationship between this POLYMORPHISM and BD. But when gender association analysis was adjusted for gender, the results showed that the frequency of AA genotype in female patients and controls was respectively 16 (66.67%) and 14 (43.75%) with p=0.00 and the frequency of GG genotype in female patients and controls was respectively 0 (0%) and 6 (18.75%) with p=0.00. A allele frequency was 40 (83.33%) in female patients and 40 (62.5%) in female control with p=0.00 and G allele frequency was 8 (16.67%) in female patients and 24 (37.5%) in female controls with p=0.00.Conclusion: The present study did not show any significant correlation between POLYMORPHISMs - 2518A/GMCP-1 gene and Behçet disease in the population of the North West of Iran. However, there was a significant association between this POLYMORPHISM and women with Behcet's disease by performing gender-related analysis. High frequency of AA genotypes and low frequency of GG genotype in female patients compared to females control suggest a very strong association between the genotypes of this POLYMORPHISM with BD in female population of the North West of Iran. A allele seems to display a protective association, whereas G allele might be a susceptible factor for females suffering BD in North West of Iran.

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References

BEHCETS DISEASE: IS THERE GEOGRAPHICAL VARIATION? A REVIEW FAR FROM THE SILK ROAD

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APA: Copy

GHAFFARI LALEH, MARYAM, JABBARPOUR BONYADI, MORTEZA, & JABBARPOUR BONYADI, MOHAMMAD HOSEIN. (2017). STUDYING THE RELATIONSHIP BETWEEN POLYMORPHISMS - 2518A/GMCP-1 GENE WITH BEHCET’S DISEASE IN THE POPULATION OF THE NORTH WEST OF IRAN. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 28(6), 418-424. SID. https://sid.ir/paper/63589/en

Vancouver: Copy

GHAFFARI LALEH MARYAM, JABBARPOUR BONYADI MORTEZA, JABBARPOUR BONYADI MOHAMMAD HOSEIN. STUDYING THE RELATIONSHIP BETWEEN POLYMORPHISMS - 2518A/GMCP-1 GENE WITH BEHCET’S DISEASE IN THE POPULATION OF THE NORTH WEST OF IRAN. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2017;28(6):418-424. Available from: https://sid.ir/paper/63589/en

IEEE: Copy

MARYAM GHAFFARI LALEH, MORTEZA JABBARPOUR BONYADI, and MOHAMMAD HOSEIN JABBARPOUR BONYADI, “STUDYING THE RELATIONSHIP BETWEEN POLYMORPHISMS - 2518A/GMCP-1 GENE WITH BEHCET’S DISEASE IN THE POPULATION OF THE NORTH WEST OF IRAN,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 28, no. 6, pp. 418–424, 2017, [Online]. Available: https://sid.ir/paper/63589/en

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