EVALUATION OF THE EFFECT OF ICI118, 551, A BETA ADRENORECEPTOR ANTAGONIST, AND ALLUM, AS ADJUVANTS FOR INCREASING THE PROTECTION OF VACCINATION AGAINST SALMONELLA TYPHIMURIUM

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HASANI SOMAYEH; HOSSEINI JAZANI NIMA; SHAHABI SHAHRAM; KARAMATI SEYED AHMAD

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Journal: Studies in Medical Sciences Year:2014 | Volume:24 | Issue:11 Page(s): 851-861

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Title

EVALUATION OF THE EFFECT OF ICI118, 551, A BETA ADRENORECEPTOR ANTAGONIST, AND ALLUM, AS ADJUVANTS FOR INCREASING THE PROTECTION OF VACCINATION AGAINST SALMONELLA TYPHIMURIUM

Author(s)

HASANI SOMAYEH | HOSSEINI JAZANI NIMA | SHAHABI SHAHRAM | KARAMATI SEYED AHMAD | Issue Writer Certificate

Keywords

S. TYPHIMURIUMQ2

VACCINATIONQ3

ADJUVANTQ2

ICI 118Q2

551Q2

ALUMQ2

MOUSEQ3

Abstract

Background & Aims: In this study the efficacy of the mixture of ICI118, 551 and ALUM, as an ADJUVANT, in the induction of humoral and cellular immunity response to heat-killed Salmonella typhimurium (S.typhimurium) (HKST) as a model vaccine was investigated.Materials and Methods: BALB/c mice were divided into five groups. Mice in the experimental groups received either the HKST vaccine alone or in combination with the ADJUVANT ALUM, ICI or the ALUM-ICI mixture. Mice in the negative control group received phosphate-buffered saline. All mice were immunized twice on days 0 and 14. Two weeks after the last immunization, immune responses to S. TYPHIMURIUM were assessed.Results: Administration of the ALUM-ICI mixture as an ADJUVANT increased the ability of the HKST vaccine after administration of sub-lethal doses of bacteria in reduction of the colony count after liver and spleen cultures, increased S. TYPHIMURIUM specific IgG and IgG2a and the survival rate after challenge with lethal doses of bacteria in the MOUSE model.Conclusion: Administration of the ALUM-ICI mixture in combination with the HKST vaccine enhanced humoral and cellular immunity in a MOUSE model.

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APA: Copy

HASANI, SOMAYEH, HOSSEINI JAZANI, NIMA, SHAHABI, SHAHRAM, & KARAMATI, SEYED AHMAD. (2014). EVALUATION OF THE EFFECT OF ICI118, 551, A BETA ADRENORECEPTOR ANTAGONIST, AND ALLUM, AS ADJUVANTS FOR INCREASING THE PROTECTION OF VACCINATION AGAINST SALMONELLA TYPHIMURIUM. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 24(11), 851-861. SID. https://sid.ir/paper/63659/en

Vancouver: Copy

HASANI SOMAYEH, HOSSEINI JAZANI NIMA, SHAHABI SHAHRAM, KARAMATI SEYED AHMAD. EVALUATION OF THE EFFECT OF ICI118, 551, A BETA ADRENORECEPTOR ANTAGONIST, AND ALLUM, AS ADJUVANTS FOR INCREASING THE PROTECTION OF VACCINATION AGAINST SALMONELLA TYPHIMURIUM. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2014;24(11):851-861. Available from: https://sid.ir/paper/63659/en

IEEE: Copy

SOMAYEH HASANI, NIMA HOSSEINI JAZANI, SHAHRAM SHAHABI, and SEYED AHMAD KARAMATI, “EVALUATION OF THE EFFECT OF ICI118, 551, A BETA ADRENORECEPTOR ANTAGONIST, AND ALLUM, AS ADJUVANTS FOR INCREASING THE PROTECTION OF VACCINATION AGAINST SALMONELLA TYPHIMURIUM,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 24, no. 11, pp. 851–861, 2014, [Online]. Available: https://sid.ir/paper/63659/en

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