LIVER FUNCTION TESTS IN CHILDREN

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FALLAHI GH.; BAGHERIAN R.

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Journal Paper

Paper Information

Journal: Iranian Journal of Pediatrics Year:2014 | Volume:24 | Issue:2 (SUPPLEMENT) Page(s): 16-16

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Information Journal Paper

Title

LIVER FUNCTION TESTS IN CHILDREN

Author(s)

FALLAHI GH. | BAGHERIAN R.

Keywords

LIVER DISEASES

LIVER FUNCTION TEST

CHILDREN

Abstract

Liver, the largest internal organ in the body has many complex functions. It acts as a filter of the blood received from the GI tract through the portal vein. It synthesizes proteins that are involved in vital functions and is an important site of carbohydrate, protein and lipid metabolism. It detoxifies toxins, metabolizes drugs and hormones, conjugates bilirubin and excretes it through the bile. Liver dysfunction, therefore, has catastrophic consequences on the body. LIVER FUNCTION TESTs comprise of a battery of tests that are used: a. as a tool for screening and documenting liver injury, to provide vital clues to the etiology of liver disease, to monitor the disease progression and response to treatment and to assess prognosis in CHILDREN with liver failure. The LIVER FUNCTION TESTs can be categorized into five: A. Tests to detect hepatocyte injury B. Tests to detect cholestasis or impaired bile flow C. Tests that assess synthetic function of liver D. Tests that assess metabolic and excretory function of liver E. Tests that assess liver fibrosis. Appropriate utilization of the tests requires knowledge of the injury patterns in LIVER DISEASES.1. LIVER FUNCTION TESTs must be interpreted in the context of a clinical diagnosis 2. These tests lack sensitivity and so normal results do not confirm absence of disease. 3. LIVER FUNCTION TESTs are useful in identifying the pattern of liver disease rather than arriving at an etiological diagnosis. 4. Age specific normal values have to be employed when interpreting lab tests like alkaline phosphatase, GGT and prothrombin time. 5. Gross elevation of transaminases occurs in primary hepatocellular diseases while ALP and GGT are very high in cholestatic diseases. 6. Increasnig bilirubin with falling transaminases denotes poor prognosis in acute severe failure.

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APA: Copy

FALLAHI, GH., & BAGHERIAN, R.. (2014). LIVER FUNCTION TESTS IN CHILDREN. IRANIAN JOURNAL OF PEDIATRICS, 24(2 (SUPPLEMENT)), 16-16. SID. https://sid.ir/paper/636665/en

Vancouver: Copy

FALLAHI GH., BAGHERIAN R.. LIVER FUNCTION TESTS IN CHILDREN. IRANIAN JOURNAL OF PEDIATRICS[Internet]. 2014;24(2 (SUPPLEMENT)):16-16. Available from: https://sid.ir/paper/636665/en

IEEE: Copy

GH. FALLAHI, and R. BAGHERIAN, “LIVER FUNCTION TESTS IN CHILDREN,” IRANIAN JOURNAL OF PEDIATRICS, vol. 24, no. 2 (SUPPLEMENT), pp. 16–16, 2014, [Online]. Available: https://sid.ir/paper/636665/en

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