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Information Journal Paper

Title

AN ASSOCIATION STUDY BETWEEN INSR/NSII (RS2059806) AND INSR/PMLI (RS1799817) SNPS IN WOMEN WITH POLYCYSTIC OVARY SYNDROME FROM WEST AZERBAIJAN PROVINCE, IRAN

Pages

  109-112

Abstract

 Background: It has been demonstrated that insulin signaling pathway related genes have important roles in POLYCYSTIC OVARY SYNDROME (PCOS) risk. The goal of present investigation was to assess the potential association between INSR/NsiI (rs2059806) and INSR/PmlI (rs1799817) SNPs and PCOS.Methods: 50 women with PCOS and 47 normal controls entered the study. NsiI and PmlI SNPs in the INSR gene were determined by RFLP-PCR.Results: INSR/NsiI (rs2059806) SNP GG, GA, AA, G and A genotypic and allelic frequencies were 45(90%), 5(10%), 0(0%), 95 (95%) and 5 (5%) in cases and 41 (87.2%), 6 (12.8%), 0 (0%), 88 (93.6%) and 6(6.38%) in controls, respectively. INSR/ PmlI (rs1799817) SNPs resulted in three genotypes of CC, CT, and TT with C and T alleles. The frequencies of PmlI (rs1799817) SNPs in the INSR gene were 37 (37%) and 63 (63%) in cases, also 39 (41.49%) and 55 (58.51%) in controls regarding T and C alleles. The frequencies of PmlI (rs1799817) SNPs in the INSR gene were 4 (8%), 29 (58%), and 17 (34%) in cases, also 5(10.64%), 29 (61.7%), and 13 (27.66%) in controls regarding TT, TC, and CC genotypes, respectively.Conclusion: The present study as the first investigation of its own kind in Iranian Azeri Turkish women, reported no association between NsiI (rs2059806) and PmlI (rs1799817) SNPs in the INSR gene and PCOS risk.

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    Cite

    APA: Copy

    BAGHERI, MORTEZA, ABDI RAD, ISA, HOSSEINI JAZANI, NIMA, ZARRIN, RASOUL, NANBAKHSH, FARIBA, & MOHAM MADZAIE, NAUMAN. (2015). AN ASSOCIATION STUDY BETWEEN INSR/NSII (RS2059806) AND INSR/PMLI (RS1799817) SNPS IN WOMEN WITH POLYCYSTIC OVARY SYNDROME FROM WEST AZERBAIJAN PROVINCE, IRAN. JOURNAL OF REPRODUCTION AND INFERTILITY, 16(2), 109-112. SID. https://sid.ir/paper/637246/en

    Vancouver: Copy

    BAGHERI MORTEZA, ABDI RAD ISA, HOSSEINI JAZANI NIMA, ZARRIN RASOUL, NANBAKHSH FARIBA, MOHAM MADZAIE NAUMAN. AN ASSOCIATION STUDY BETWEEN INSR/NSII (RS2059806) AND INSR/PMLI (RS1799817) SNPS IN WOMEN WITH POLYCYSTIC OVARY SYNDROME FROM WEST AZERBAIJAN PROVINCE, IRAN. JOURNAL OF REPRODUCTION AND INFERTILITY[Internet]. 2015;16(2):109-112. Available from: https://sid.ir/paper/637246/en

    IEEE: Copy

    MORTEZA BAGHERI, ISA ABDI RAD, NIMA HOSSEINI JAZANI, RASOUL ZARRIN, FARIBA NANBAKHSH, and NAUMAN MOHAM MADZAIE, “AN ASSOCIATION STUDY BETWEEN INSR/NSII (RS2059806) AND INSR/PMLI (RS1799817) SNPS IN WOMEN WITH POLYCYSTIC OVARY SYNDROME FROM WEST AZERBAIJAN PROVINCE, IRAN,” JOURNAL OF REPRODUCTION AND INFERTILITY, vol. 16, no. 2, pp. 109–112, 2015, [Online]. Available: https://sid.ir/paper/637246/en

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