CYTOTOXIC AND INHIBITORY EFFECTS OF GLYCYRRHIZA GLABRA AND MATRICARIA AUREA EXTRACTS ON METALLOPROTEINASE MATRIX ACTIVITY IN COMPARISON WITH STEROIDAL AND NON STEROIDAL COMPOUNDS IN FIBROSARCOMA CELL LINE CULTURE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

AGHEL N.; KHODADADI ALI; ESMAEILIAN MAJID

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Studies in Medical Sciences Year:2008 | Volume:19 | Issue:2 Page(s): 132-138

Download Full-Text

Persian Verion

View:

989

Download:

Cites:

Information Journal Paper

Title

CYTOTOXIC AND INHIBITORY EFFECTS OF GLYCYRRHIZA GLABRA AND MATRICARIA AUREA EXTRACTS ON METALLOPROTEINASE MATRIX ACTIVITY IN COMPARISON WITH STEROIDAL AND NON STEROIDAL COMPOUNDS IN FIBROSARCOMA CELL LINE CULTURE

Author(s)

AGHEL N. | KHODADADI ALI | ESMAEILIAN MAJID | Issue Writer Certificate

Keywords

METALLOPROTEINASE MATRIXQ3

GLYCYRRHIZA GLABRAQ3

MATRICARIA AUREAQ3

CYTOTOXICITYQ3

Abstract

Background & Aims: METALLOPROTEINASE MATRIX (MMPs), a family of zinc and calcium dependent enzymes, is produced by a wide range of stromal and inflammatory cells. MMPs are capable of degrading all of the compounds of extra cellular matrix. The role of METALLOPROTEINASE MATRIX in pathophysiology of various inflammatory diseases, such as arthritis, cardiovascular disease, and cancer is well known. The previous studies have shown that dexamethasone and non steroidal anti inflammatory drugs (NSAIDs) have inhibitory effect on METALLOPROTEINASE MATRIX activity. The aim of the present study was to investigate the inhibitory and cytotoxic effects of GLYCYRRHIZA GLABRA and MATRICARIA AUREA hydroalcoholic extracts on METALLOPROTEINASE MATRIX activity in comparison with diclofenac, piroxicam, and dexamethasone. Materials & Methods: Herbal extracts were prepared by percolation method, then gelatin zymography and cellular CYTOTOXICITY methods were employed using fibrosarcoma cell line culture (Wehi 164). Results: Our results indicated that all drugs and herbal extracts showed dose-dependent reduction in METALLOPROTEINASE MATRIX activity. Herbal extracts showed this effect in higher doses but they had lower CYTOTOXICITY compared to other drugs. Conclusion: MATRICARIA AUREA extract, as compared to GLYCYRRHIZA GLABRA, have low toxicity effect (IC50=3450 mg/ml) and better inhibitory activity (IC50=933.33 mg/ml) upon MMPs.

Cites

THE CYTOTOXIC EFFECTS OF GLYCYRRHIZA GLABRA L. ROOT EXTRACT ON 4T1 CELL LINE DERIVED FROM BALB/C MICE MAMMARY TUMORS

References

No record.

Cite

APA: Copy

AGHEL, N., KHODADADI, ALI, & ESMAEILIAN, MAJID. (2008). CYTOTOXIC AND INHIBITORY EFFECTS OF GLYCYRRHIZA GLABRA AND MATRICARIA AUREA EXTRACTS ON METALLOPROTEINASE MATRIX ACTIVITY IN COMPARISON WITH STEROIDAL AND NON STEROIDAL COMPOUNDS IN FIBROSARCOMA CELL LINE CULTURE. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 19(2), 132-138. SID. https://sid.ir/paper/63727/en

Vancouver: Copy

AGHEL N., KHODADADI ALI, ESMAEILIAN MAJID. CYTOTOXIC AND INHIBITORY EFFECTS OF GLYCYRRHIZA GLABRA AND MATRICARIA AUREA EXTRACTS ON METALLOPROTEINASE MATRIX ACTIVITY IN COMPARISON WITH STEROIDAL AND NON STEROIDAL COMPOUNDS IN FIBROSARCOMA CELL LINE CULTURE. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2008;19(2):132-138. Available from: https://sid.ir/paper/63727/en

IEEE: Copy

N. AGHEL, ALI KHODADADI, and MAJID ESMAEILIAN, “CYTOTOXIC AND INHIBITORY EFFECTS OF GLYCYRRHIZA GLABRA AND MATRICARIA AUREA EXTRACTS ON METALLOPROTEINASE MATRIX ACTIVITY IN COMPARISON WITH STEROIDAL AND NON STEROIDAL COMPOUNDS IN FIBROSARCOMA CELL LINE CULTURE,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 19, no. 2, pp. 132–138, 2008, [Online]. Available: https://sid.ir/paper/63727/en

Related Journal Papers