مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

THE USE OF SINGLE VERSUS DOUBLE DOSE OF INTRA-VAGINAL PROSTAGLANDIN E22 “MISOPROSTOL” PRIOR TO ABDOMINAL MYOMECTOMY: A RANDOMIZED CONTROLLED CLINICAL TRIAL

Pages

  152-156

Abstract

 Background: The study aimed to investigate the effectiveness of a single versus DOUBLE DOSE of prostaglandin E2 “misoprostol, 400 microgram” prior to myomectomy for multiple uterine fibroids.Methods: This was a prospective randomized controlled trial comprised of 69 patients with multiple myomas undergoing myomectomy. Patients received either an intra-vaginal single dose of 400 microgram MISOPROSTOL 1 hr pre-operatively (group A, 34 cases) or 2 doses, 3 and 1 hr prior to surgery (group B, 35 cases). Operation time, intra and post-operative blood loss, hemoglobin concentration, blood pressure and body's temperature were estimated and compared in both groups. The data were statistically analyzed using chi-square test. The p<0.05 was considered significant.Results: In group B, the mean operative time was significantly (p<0.001) shorter than in group A (25.8±4.14 vs. 35.4±5.6 min respectively). The mean value for operative blood loss was significantly (p<0.001) smaller in group B (101.4±25.5 vs. 200.16±18.8 ml). There was a significant (p<0.01) rise of the body temperature in group B (38.5±0.7 vs. 37.18±0.84oC). There were no differences between the two groups regarding hemoglobin levels, post-operative febrile morbidity or length of hospital stay.Conclusion: In this study, two doses of pre-operative intra-vaginal MISOPROSTOL were more effective than one dose in reducing intra and post-operative blood loss and shortening of operation time during ABDOMINAL MYOMECTOMY.

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    Cite

    APA: Copy

    RAGAB, AHMED, KHAIARY, MOUSTAFA, & BADAWY, AHMED. (2014). THE USE OF SINGLE VERSUS DOUBLE DOSE OF INTRA-VAGINAL PROSTAGLANDIN E22 “MISOPROSTOL” PRIOR TO ABDOMINAL MYOMECTOMY: A RANDOMIZED CONTROLLED CLINICAL TRIAL. JOURNAL OF REPRODUCTION AND INFERTILITY, 15(3 (60)), 152-156. SID. https://sid.ir/paper/638091/en

    Vancouver: Copy

    RAGAB AHMED, KHAIARY MOUSTAFA, BADAWY AHMED. THE USE OF SINGLE VERSUS DOUBLE DOSE OF INTRA-VAGINAL PROSTAGLANDIN E22 “MISOPROSTOL” PRIOR TO ABDOMINAL MYOMECTOMY: A RANDOMIZED CONTROLLED CLINICAL TRIAL. JOURNAL OF REPRODUCTION AND INFERTILITY[Internet]. 2014;15(3 (60)):152-156. Available from: https://sid.ir/paper/638091/en

    IEEE: Copy

    AHMED RAGAB, MOUSTAFA KHAIARY, and AHMED BADAWY, “THE USE OF SINGLE VERSUS DOUBLE DOSE OF INTRA-VAGINAL PROSTAGLANDIN E22 “MISOPROSTOL” PRIOR TO ABDOMINAL MYOMECTOMY: A RANDOMIZED CONTROLLED CLINICAL TRIAL,” JOURNAL OF REPRODUCTION AND INFERTILITY, vol. 15, no. 3 (60), pp. 152–156, 2014, [Online]. Available: https://sid.ir/paper/638091/en

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