POLYMORPHISM OF 1691G>A, V COAGULATION FACTOR GENE IN THE HEALTHY POPULATION OF EAST AZERBAIJAN PROVINCE OF IRAN

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MONFAREDAN AMIR; FARSHDOUSTI HAGH MAJID; SHAMS KARIM; TALEBI MEHDI; BARGAHI NASRIN; MOVASSAGHPOUR AKBARI ALI AKBAR

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Journal: Studies in Medical Sciences Year:2013 | Volume:24 | Issue:3 Page(s): 219-225

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Title

POLYMORPHISM OF 1691G>A, V COAGULATION FACTOR GENE IN THE HEALTHY POPULATION OF EAST AZERBAIJAN PROVINCE OF IRAN

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Keywords

POINT MUTATIONQ2

FACTOR 5 LEIDENQ3

ALLELIC FREQUENCYQ2

G1691AQ2

Abstract

Background & Aims: Genetic mutation, 1691G>A common polymorphism in a gene that is inherited coagulation Factor 5 is associated with increased risk of thrombosis. This mutation in different populations can develop in the prognosis of thrombotic disorders, cardiovascular disorders; recurrent miscarriage and other thrombotic factors are useful. Study using appropriate strategies such as review of medical and epidemiological information will be helpful for future studies. In this study, the frequency of the mutation 1691G> A in the gene for clotting factor 5 in a healthy population of East Azerbaijan province was investigated.Materials & Methods: This study was conducted on 200 normal individuals with no history of cardiovascular disease by eliminating patients with a history, as an example of Northwest's population. After obtaining blood and ARMS-PCR to determine the frequency of alleles with G1691A, mutation of coagulation factor 5 was attempted.Results: The frequency of G allele in 86% of females and males was 91%, while the A allele frequency in females and 14 males was 9%. ALLELIC FREQUENCY of G>A mutation in factor V for GG, GA and AA genotypes were 0.94, 0.06 and 0, respectively.Conclusion: In our country, according to several ethnic members including a variety of native Persians, Turks, Kurds, Lors, Baluchis, Arabs, Bakhtiari, Turkmen, and Armenians, the allele frequencies for FACTOR 5 LEIDEN part of the region Ethnicity is a different disease.

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APA: Copy

MONFAREDAN, AMIR, FARSHDOUSTI HAGH, MAJID, SHAMS, KARIM, TALEBI, MEHDI, BARGAHI, NASRIN, & MOVASSAGHPOUR AKBARI, ALI AKBAR. (2013). POLYMORPHISM OF 1691G>A, V COAGULATION FACTOR GENE IN THE HEALTHY POPULATION OF EAST AZERBAIJAN PROVINCE OF IRAN. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 24(3), 219-225. SID. https://sid.ir/paper/63820/en

Vancouver: Copy

MONFAREDAN AMIR, FARSHDOUSTI HAGH MAJID, SHAMS KARIM, TALEBI MEHDI, BARGAHI NASRIN, MOVASSAGHPOUR AKBARI ALI AKBAR. POLYMORPHISM OF 1691G>A, V COAGULATION FACTOR GENE IN THE HEALTHY POPULATION OF EAST AZERBAIJAN PROVINCE OF IRAN. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2013;24(3):219-225. Available from: https://sid.ir/paper/63820/en

IEEE: Copy

AMIR MONFAREDAN, MAJID FARSHDOUSTI HAGH, KARIM SHAMS, MEHDI TALEBI, NASRIN BARGAHI, and ALI AKBAR MOVASSAGHPOUR AKBARI, “POLYMORPHISM OF 1691G>A, V COAGULATION FACTOR GENE IN THE HEALTHY POPULATION OF EAST AZERBAIJAN PROVINCE OF IRAN,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 24, no. 3, pp. 219–225, 2013, [Online]. Available: https://sid.ir/paper/63820/en

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