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Information Journal Paper

Title

ANTIHYPERTENSIVE EFFECT OF AURAPTENE, A MONOTERPENE COUMARIN FROM THE GENUS CITRUS, UPON CHRONIC ADMINISTRATION

Pages

  153-158

Abstract

 Objective(s): Auraptene, a monoterpene coumarin from Citrus species, exhibits cardioprotective effects. In this study, the effects of auraptene administration were investigated on BLOOD PRESSURE of normotensive and desoxycorticosterone acetate (DOCA) salt induced hypertensive rats.Materials and Methods: Five weeks administration of auraptene (2, 4, 8 and 16 mg/kg/day) and nifedipine (0.25, 0.5, 1, 2 and 4 mg/kg/day) in different groups of normotensive and hypertensive rats (at the end of 3 weeks treatment by DOCA SALT) was carried out and their effects on mean systolic BLOOD PRESSURE (MSBP) and mean heart rate (MHR) were evaluated using tail cuff method.Results: Our results indicated that chronic administration of auraptene (2, 4, 8 and 16 mg/kg/day) significantly reduced the MSBP in DOCA SALT treated rats in a dose and time dependent manner. The percent of decreases in MSBP levels by the highest dose of auraptene (16 mg/kg) at the end of 4th to 8th weeks, were 7.00%, 10.78%, 16.07%, 21.28% and 27.54% respectively (P<0.001). Moreover the antihypertensive effect of auraptene was less than nifedipine (ED50 value of nifedipine=0.7 mg/kg at 8th week and ED50 value of auraptene=5.64 mg/kg at 8 week).Conclusion: Auraptene considerably reduced MSBP in hypertensive rats, but not in normotensive (normal saline treated) rats. The results of MHR measurement showed that the increase in MHR was not significant in comparison with DOCA treated rats.

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    APA: Copy

    RAZAVI, BIBI MARJAN, ARASTEH, EBRAHIM, IMENSHAHIDI, MOHSEN, & IRANSHAHI, MEHRDAD. (2015). ANTIHYPERTENSIVE EFFECT OF AURAPTENE, A MONOTERPENE COUMARIN FROM THE GENUS CITRUS, UPON CHRONIC ADMINISTRATION. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 18(2), 153-158. SID. https://sid.ir/paper/638264/en

    Vancouver: Copy

    RAZAVI BIBI MARJAN, ARASTEH EBRAHIM, IMENSHAHIDI MOHSEN, IRANSHAHI MEHRDAD. ANTIHYPERTENSIVE EFFECT OF AURAPTENE, A MONOTERPENE COUMARIN FROM THE GENUS CITRUS, UPON CHRONIC ADMINISTRATION. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2015;18(2):153-158. Available from: https://sid.ir/paper/638264/en

    IEEE: Copy

    BIBI MARJAN RAZAVI, EBRAHIM ARASTEH, MOHSEN IMENSHAHIDI, and MEHRDAD IRANSHAHI, “ANTIHYPERTENSIVE EFFECT OF AURAPTENE, A MONOTERPENE COUMARIN FROM THE GENUS CITRUS, UPON CHRONIC ADMINISTRATION,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 18, no. 2, pp. 153–158, 2015, [Online]. Available: https://sid.ir/paper/638264/en

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