ASSOCIATION BETWEEN XPD (LYS751G1N) POLYMORPHISM AND LUNG CANCER RISK: A POPULATION-BASED STUDY IN IRAN

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOTOVALI BASHI MAJID; REZAEI HOJATOLLAH; DEHGHANIAN FARIBA; REZAEI HALIMEH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Cell Journal (Yakhteh) Year:2014 | Volume:16 | Issue:3 (63) Page(s): 309-314

Download Full-Text

View:

381

Download:

224

Cites:

Information Journal Paper

Title

ASSOCIATION BETWEEN XPD (LYS751G1N) POLYMORPHISM AND LUNG CANCER RISK: A POPULATION-BASED STUDY IN IRAN

Author(s)

MOTOVALI BASHI MAJID | REZAEI HOJATOLLAH | DEHGHANIAN FARIBA | REZAEI HALIMEH | Issue Writer Certificate

Keywords

XPD

LUNG CANCER

POLYMORPHISM

IRANIAN

RFLP

NER

Abstract

Objective: People are usually susceptible to carcinogenic aromatic amines, present in cigarrette smoke and polluted environment, which can cause DNA damage. Therefore, maintenance of genomic DNA integrity is a direct result of proper function of DNA repair enzymes. Polymorphic diversity could affect the function of repair enzymes and thus augment the risk of different cancers. Xeroderma pigmentosum group D (XPD) gene encodes one of the most prominent repair enzymes and the POLYMORPHISMs of this gene are thought to be of importance in LUNG CANCER risk. This gene encodes the helicase, which is a component of transcription factor IIH and an important part of the nucleotide excision repair system. Studies reveal that individuals with Lys751Gln POLYMORPHISM of XPD gene have a low repairing capacity to delete the damages of ultraviolet light among other XPD POLYMORPHISMs.Materials and Methods: In this case-control study, first Lys751Gln POLYMORPHISM was genotyped, then its association with LUNG CANCER risk was analyzed. Genomic DNA was extracted from the whole blood sample of 640 individuals from Iran (352 healthy individuals and 288 patients). Allele frequencies and heterozygosity of Lys751Gln POLYMORPHISM were determined using polymerase chain reaction-restriction fragment length POLYMORPHISM method.Results: According to statistical analyses, LUNG CANCER risk in individuals with Lys751Gln POLYMORPHISM (Odd Ratio=1.8, 95% Confidence Interval 0.848-3.819) is approximately twice as high as that of Lys/Lys genotype, however 751Gln/Gln genotype did not relate to LUNG CANCER risk (Odd Ratio=0.7, 95% Confidence Interval 0.307-1.595).Conclusion: This study suggests that heterozygous POLYMORPHISM (Lys/Gln) increases the sensitivity of LUNG CANCER risk, while homozygous POLYMORPHISM (Lys/Lys) probably decreases its risk and C allele frequency shows no remarkable increase in the patients.

Cites

THE ESSENTIALITY OF REPORTING HARDY-WEINBERG EQUILIBRIUM CALCULATIONS IN POPULATION-BASED GENETIC ASSOCIATION STUDIES (DEBATE)

References

Cite

APA: Copy

MOTOVALI BASHI, MAJID, REZAEI, HOJATOLLAH, DEHGHANIAN, FARIBA, & REZAEI, HALIMEH. (2014). ASSOCIATION BETWEEN XPD (LYS751G1N) POLYMORPHISM AND LUNG CANCER RISK: A POPULATION-BASED STUDY IN IRAN. CELL JOURNAL (YAKHTEH), 16(3 (63)), 309-314. SID. https://sid.ir/paper/638409/en

Vancouver: Copy

MOTOVALI BASHI MAJID, REZAEI HOJATOLLAH, DEHGHANIAN FARIBA, REZAEI HALIMEH. ASSOCIATION BETWEEN XPD (LYS751G1N) POLYMORPHISM AND LUNG CANCER RISK: A POPULATION-BASED STUDY IN IRAN. CELL JOURNAL (YAKHTEH)[Internet]. 2014;16(3 (63)):309-314. Available from: https://sid.ir/paper/638409/en

IEEE: Copy

MAJID MOTOVALI BASHI, HOJATOLLAH REZAEI, FARIBA DEHGHANIAN, and HALIMEH REZAEI, “ASSOCIATION BETWEEN XPD (LYS751G1N) POLYMORPHISM AND LUNG CANCER RISK: A POPULATION-BASED STUDY IN IRAN,” CELL JOURNAL (YAKHTEH), vol. 16, no. 3 (63), pp. 309–314, 2014, [Online]. Available: https://sid.ir/paper/638409/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops