SYNTHESISOF CHOLESTEROL GRAFTED MOLECULALRY IMPRINTED POLYMER BY MEANS OF THE SILANATION OF MAGNETIC PARTICLES AND EVALUTAION OF FUNCTIONAL CHARACTERISTICS

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MOGHADDAS KIA EHSAN; ALIZADEH MOHAMMAD; VARDAST MOHAMMAD REZA; REZAZADE MAHMOUD

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Journal: Studies in Medical Sciences Year:2016 | Volume:27 | Issue:3 Page(s): 231-239

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Title

SYNTHESISOF CHOLESTEROL GRAFTED MOLECULALRY IMPRINTED POLYMER BY MEANS OF THE SILANATION OF MAGNETIC PARTICLES AND EVALUTAION OF FUNCTIONAL CHARACTERISTICS

Author(s)

MOGHADDAS KIA EHSAN | ALIZADEH MOHAMMAD | VARDAST MOHAMMAD REZA | REZAZADE MAHMOUD | Issue Writer Certificate

Keywords

CHOLESTEROLQ3

GRAFTED MOLECULARLY IMPRINTED POLYMERQ1

MAGNETIC FE3O4 NANOPARTICLESQ1

Abstract

Background & Aims: Nowadays usage of molecularly imprinted polymers which act as artificial antibodies and separate target molecules from biological environments is a novel approach. CHOLESTEROL is one of the major risk factors of cardiovascular diseases and its precise determination is crucial. In this research, a molecularly imprinted polymer by means of Fe3O4 nanoparticles coated with silica layer was fabricated and its functional characteristics were investigated.Materials & Methods: Co-precipitation method was used for manufacturing of MAGNETIC FE3O4 NANOPARTICLES coated by silica. Then CHOLESTEROL imprinted polymer were synthesized by grafting coreshell procedure. Finally obtained polymer was eluted by mixture of solvents to create specific adsorbent active sites for CHOLESTEROL. The polymer was incubated with CHOLESTEROL stock solution and binding activity was determined through high performance liquid chromatography. Structure and morphology of samples were evaluated by FT-IR spectroscopy and scanning electron microscopy.Results: Optimized ratio of polymer weight to CHOLESTEROL stock solution volume showed 94% separation from 100 mg/L stock solution. FT-IR spectrometry results revealed a fine coating of silica for magneticFe3O4cores.Silica band which was adsorbent of template molecule was intensified by sol-gel polymerization method. Polymer morphology was porous, spherical shaped and particle dimensions were observed less than 50 nanometers.Conclusion: Application of Fe3O4 nanoparticles coated with silica in this method enables high separation of CHOLESTEROL which could be due to ease of extraction and grafted polymer nature.Morphology of adsorbent polymers indicated performance of nano surfaces in separation of this compound.

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APA: Copy

MOGHADDAS KIA, EHSAN, ALIZADEH, MOHAMMAD, VARDAST, MOHAMMAD REZA, & REZAZADE, MAHMOUD. (2016). SYNTHESISOF CHOLESTEROL GRAFTED MOLECULALRY IMPRINTED POLYMER BY MEANS OF THE SILANATION OF MAGNETIC PARTICLES AND EVALUTAION OF FUNCTIONAL CHARACTERISTICS. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 27(3), 231-239. SID. https://sid.ir/paper/63971/en

Vancouver: Copy

MOGHADDAS KIA EHSAN, ALIZADEH MOHAMMAD, VARDAST MOHAMMAD REZA, REZAZADE MAHMOUD. SYNTHESISOF CHOLESTEROL GRAFTED MOLECULALRY IMPRINTED POLYMER BY MEANS OF THE SILANATION OF MAGNETIC PARTICLES AND EVALUTAION OF FUNCTIONAL CHARACTERISTICS. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2016;27(3):231-239. Available from: https://sid.ir/paper/63971/en

IEEE: Copy

EHSAN MOGHADDAS KIA, MOHAMMAD ALIZADEH, MOHAMMAD REZA VARDAST, and MAHMOUD REZAZADE, “SYNTHESISOF CHOLESTEROL GRAFTED MOLECULALRY IMPRINTED POLYMER BY MEANS OF THE SILANATION OF MAGNETIC PARTICLES AND EVALUTAION OF FUNCTIONAL CHARACTERISTICS,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 27, no. 3, pp. 231–239, 2016, [Online]. Available: https://sid.ir/paper/63971/en

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