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Information Journal Paper

Title

8-OH-DPAT (5-HT1A AGONIST) ATTENUATES 6-HYDROXY-DOPAMINE-INDUCED CATALEPSY AND MODULATES INFLAMMATORY CYTOKINES IN RATS

Pages

  1270-1275

Abstract

 Objective (s): Neuroinflammation in Parkinson disease (PD) is associated with glial cells activation and production of different inflammatory cytokines. In this study, we investigated the effect of chronic administration of 8-OH-DPAT on 6-OHDA-induced catalepsy and levels of inflammatory cytokines in cerebrospinal fluid (CSF).Materials and Methods: Catalepsy was induced by unilateral infusion of 6-OHDA (8 mg/2 ml/rat) into the central region of the sabstantia nigra pars compacta (SNc) being assessed by the bar-test, 5, 60, 120 and 180 min after intraperitoneal (IP) administration of 8-OH-DPAT (5-HT1A receptor agonist; 0.25, 0.5 and 1mg/kg, IP for 10 days). CSF samples were collected on the tenth day of 8-OH-DPAT administration and analyzed by ELISA method to measure levels of TNF-a, IL-1b and IL-6.Results: Chronic injection of 8-OH-DPAT decreased catalepsy in a dose dependent manner when compared with the control group. The most anti-cataleptic effect was observed at the dose of 1 mg/kg of 8-OH-DPAT. Levels of TNF-a in CSF increased three weeks after 6-OHDA injection while there was a significant decrease in TNF-a level of parkinsonian animals treated with 8-OH-DPAT (1 mg/kg, IP for 10 days). IL-1 b and IL-6 decreased and increased in parkinsonian rats and in 8-OH-DPAT-treated parkinsonian rats, respectively.Conclusion: Our study indicated that chronic administration of 8-OH-DPAT improves catalepsy in 6- OHDA-induced animal model of PD and restores central concentration of inflammatory cytokines to the basal levels.5-HT1A receptor agonists can be suggested as potential adjuvant therapy in PD by modulation of cerebral inflammatory cytokines.

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    APA: Copy

    SHARIFI, HAMDOLAH, MOHAJJEL NAYEBI, ALIREZA, & FARAJNIA, SAFAR. (2013). 8-OH-DPAT (5-HT1A AGONIST) ATTENUATES 6-HYDROXY-DOPAMINE-INDUCED CATALEPSY AND MODULATES INFLAMMATORY CYTOKINES IN RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 16(12), 1270-1275. SID. https://sid.ir/paper/640040/en

    Vancouver: Copy

    SHARIFI HAMDOLAH, MOHAJJEL NAYEBI ALIREZA, FARAJNIA SAFAR. 8-OH-DPAT (5-HT1A AGONIST) ATTENUATES 6-HYDROXY-DOPAMINE-INDUCED CATALEPSY AND MODULATES INFLAMMATORY CYTOKINES IN RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2013;16(12):1270-1275. Available from: https://sid.ir/paper/640040/en

    IEEE: Copy

    HAMDOLAH SHARIFI, ALIREZA MOHAJJEL NAYEBI, and SAFAR FARAJNIA, “8-OH-DPAT (5-HT1A AGONIST) ATTENUATES 6-HYDROXY-DOPAMINE-INDUCED CATALEPSY AND MODULATES INFLAMMATORY CYTOKINES IN RATS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 16, no. 12, pp. 1270–1275, 2013, [Online]. Available: https://sid.ir/paper/640040/en

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