DOUBLE-BLINDED, RANDOMIZED, PLACEBO-CONTROLLED STUDY TO EVALUATE THE EFFECTIVENESS OF GREEN TEA IN PREVENTING ACUTE GASTROINTESTINAL COMPLICATIONS DUE TO RADIOTHERAPY

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EMAMI HAMID; NIKOOBIN FARZANEH; ROAYAEI MAHNAZ; ZIYA HAMID REZA

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Journal Paper

Paper Information

Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2014 | Volume:19 | Issue:5 Page(s): 445-450

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Title

DOUBLE-BLINDED, RANDOMIZED, PLACEBO-CONTROLLED STUDY TO EVALUATE THE EFFECTIVENESS OF GREEN TEA IN PREVENTING ACUTE GASTROINTESTINAL COMPLICATIONS DUE TO RADIOTHERAPY

Author(s)

EMAMI HAMID | NIKOOBIN FARZANEH | ROAYAEI MAHNAZ | ZIYA HAMID REZA | Issue Writer Certificate

Keywords

ABDOMEN IRRADIATION

CANCER

GREEN TEA

PELVIC IRRADIATION

RADIOTHERAPY INDUCED DIARRHEA

Abstract

Background: Radiation-induced discomfort is frequently observed during pelvic radiotherapy. This study was performed to determine the effect of a GREEN TEA tablet to reduce the incidence of radiation-induced diarrhea and vomiting in patients with abdomen and pelvic malignancy.Materials and Methods: This randomized controlled clinical trial recruited 42 patients with abdomen and pelvic malignancy considered for treatment with 50 Gy radiotherapy, randomly assigned to the GREEN TEA tablet 450 mg (n=21) or placebo group (n=21) for 5 weeks. Acute gastrointestinal complications (Diarrhea and vomiting) were weekly assessed using Common Toxicity Criteria of the National CANCER Institute version 3.0 and functional living index emesis, respectively. Two sample t-tests, Pearson’s Chi-square, Mann-Whitney U-test, and Friedman were used for analysis.Result: There was a significant difference in frequency of reported diarrhea between two groups of study at the end of study (P<0.002). About 81% of patients in GREEN TEA group reported no history of diarrhea at week 5. The treatment groups have reported no history of severe diarrhea during radiotherapy. There was no significant difference between two groups of study in frequency of vomiting throughout the study, but 9.5% of cases in placebo group showed severe vomiting.Conclusion: GREEN TEA contains a high concentration of catechins could be effective in decreasing the frequency and severity of RADIOTHERAPY INDUCED DIARRHEA. GREEN TEA (450 mg/day) could be considered to be a safe for prevention diarrhea and vomiting in patients undergoing pelvic or abdomen radiotherapy.

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APA: Copy

EMAMI, HAMID, NIKOOBIN, FARZANEH, ROAYAEI, MAHNAZ, & ZIYA, HAMID REZA. (2014). DOUBLE-BLINDED, RANDOMIZED, PLACEBO-CONTROLLED STUDY TO EVALUATE THE EFFECTIVENESS OF GREEN TEA IN PREVENTING ACUTE GASTROINTESTINAL COMPLICATIONS DUE TO RADIOTHERAPY. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 19(5), 445-450. SID. https://sid.ir/paper/640683/en

Vancouver: Copy

EMAMI HAMID, NIKOOBIN FARZANEH, ROAYAEI MAHNAZ, ZIYA HAMID REZA. DOUBLE-BLINDED, RANDOMIZED, PLACEBO-CONTROLLED STUDY TO EVALUATE THE EFFECTIVENESS OF GREEN TEA IN PREVENTING ACUTE GASTROINTESTINAL COMPLICATIONS DUE TO RADIOTHERAPY. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2014;19(5):445-450. Available from: https://sid.ir/paper/640683/en

IEEE: Copy

HAMID EMAMI, FARZANEH NIKOOBIN, MAHNAZ ROAYAEI, and HAMID REZA ZIYA, “DOUBLE-BLINDED, RANDOMIZED, PLACEBO-CONTROLLED STUDY TO EVALUATE THE EFFECTIVENESS OF GREEN TEA IN PREVENTING ACUTE GASTROINTESTINAL COMPLICATIONS DUE TO RADIOTHERAPY,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 19, no. 5, pp. 445–450, 2014, [Online]. Available: https://sid.ir/paper/640683/en

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