EFFLUX PUMP INHIBITORS EFFECT ON THE MINIMUM INHIBITORY CONCENTRATION OF BENZALKONIUM CHLORIDE AND CHLORHEXIDINE IN ACINETOBACTER BAUMANNII STRAINS ISOLATED FROM HOSPITALIZED INPATIENTS IN GAZI HOSPITAL, ANKARA

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AFSHAR YAVARI SHOHREH; ROTA SEYYAL; CAGLAR KAYAHAN; FIDAN ISIL

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Journal: Studies in Medical Sciences Year:2016 | Volume:27 | Issue:5 Page(s): 393-401

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Title

EFFLUX PUMP INHIBITORS EFFECT ON THE MINIMUM INHIBITORY CONCENTRATION OF BENZALKONIUM CHLORIDE AND CHLORHEXIDINE IN ACINETOBACTER BAUMANNII STRAINS ISOLATED FROM HOSPITALIZED INPATIENTS IN GAZI HOSPITAL, ANKARA

Author(s)

AFSHAR YAVARI SHOHREH | ROTA SEYYAL | CAGLAR KAYAHAN | FIDAN ISIL | Issue Writer Certificate

Keywords

ACINETOBACTER BAUMANNIIQ1

EFFLUX PUMP INHIBITORSQ1

1-1-NAPHTHYLMETHYL-PIPERAZINEQ1

PHENYLARGININE-β-NAPHTHYLAMIDEQ1

BENZALKONIUM CHLORIDEQ1

CHLORHEXIDINEQ1

Abstract

Background & Aims: Today, increasing resistance to antibiotics causes serious problems for treatment of patients. The aim of this study was to determine the role of AdeABC efflux pump in the BENZALKONIUM CHLORIDE and CHLORHEXIDINE MIC value with EFFLUX PUMP INHIBITORS (1-1-naphthylmethyl-piperazine and phenyl-arginine-b-naphthylamide) in the A.baumanii strains isolated from intensive care unit.Materials & Methods: This study was conducted on 50 isolates of ACINETOBACTER BAUMANNII collected from ICU wards of Gazi hospital. The species identification was performed by standard laboratory methods. BENZALKONIUM CHLORIDE and CHLORHEXIDINE MIC value were performed using microdilution method according to the clinical and laboratory standards institute (CLSI) guidelines. The activity of the efflux pump was evaluated using the EFFLUX PUMP INHIBITORS.Conclusions: The AdeABC efflux pump may play a role in decreasing BENZALKONIUM CHLORIDE and CHLORHEXIDINE MIC value in A. baumannii isolates.

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APA: Copy

AFSHAR YAVARI, SHOHREH, ROTA, SEYYAL, CAGLAR, KAYAHAN, & FIDAN, ISIL. (2016). EFFLUX PUMP INHIBITORS EFFECT ON THE MINIMUM INHIBITORY CONCENTRATION OF BENZALKONIUM CHLORIDE AND CHLORHEXIDINE IN ACINETOBACTER BAUMANNII STRAINS ISOLATED FROM HOSPITALIZED INPATIENTS IN GAZI HOSPITAL, ANKARA. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 27(5), 393-401. SID. https://sid.ir/paper/64072/en

Vancouver: Copy

AFSHAR YAVARI SHOHREH, ROTA SEYYAL, CAGLAR KAYAHAN, FIDAN ISIL. EFFLUX PUMP INHIBITORS EFFECT ON THE MINIMUM INHIBITORY CONCENTRATION OF BENZALKONIUM CHLORIDE AND CHLORHEXIDINE IN ACINETOBACTER BAUMANNII STRAINS ISOLATED FROM HOSPITALIZED INPATIENTS IN GAZI HOSPITAL, ANKARA. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2016;27(5):393-401. Available from: https://sid.ir/paper/64072/en

IEEE: Copy

SHOHREH AFSHAR YAVARI, SEYYAL ROTA, KAYAHAN CAGLAR, and ISIL FIDAN, “EFFLUX PUMP INHIBITORS EFFECT ON THE MINIMUM INHIBITORY CONCENTRATION OF BENZALKONIUM CHLORIDE AND CHLORHEXIDINE IN ACINETOBACTER BAUMANNII STRAINS ISOLATED FROM HOSPITALIZED INPATIENTS IN GAZI HOSPITAL, ANKARA,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 27, no. 5, pp. 393–401, 2016, [Online]. Available: https://sid.ir/paper/64072/en

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