EVALUATION OF INFLUENZA VACCINATION EFFECTS IN DISEASE ACTIVITY AND AUTOANTIBODY GENERATION IN SYSTEMIC LUPUS ERYTHEMATOUS

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AGHDASHI MIR AMIR; SHARIFI YAGHOOB; DERAKHSHANFAR MOSTAFA

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Journal: Studies in Medical Sciences Year:2014 | Volume:25 | Issue:1 Page(s): 51-55

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Title

EVALUATION OF INFLUENZA VACCINATION EFFECTS IN DISEASE ACTIVITY AND AUTOANTIBODY GENERATION IN SYSTEMIC LUPUS ERYTHEMATOUS

Author(s)

AGHDASHI MIR AMIR | SHARIFI YAGHOOB | DERAKHSHANFAR MOSTAFA | Issue Writer Certificate

Keywords

AUTOANTIBODYQ2

SYSTEMIC LUPUS ERYTHEMATOSUSQ2

INFLUENZA VACCINEQ2

Abstract

Background & Aims: Systemic lupus erythematous (SLE) patients are susceptible to various infections due to inappropriate immune responses and using variety of immunosuppressive therapies.In this condition, influenza vaccination is an option that seems to contribute the patients. However, there is a lack of data regarding vaccination in SLE patients in Iran that prompted us to design a study to evaluate the impact of INFLUENZA VACCINE in SLE patients.Materials & Methods: Twenty-four SLE patients were selected and underwent blood sampling for AUTOANTIBODY titers before receiving INFLUENZA VACCINE and rechecked 12 weeks after vaccination. All patients were monitored for any vaccination complications and SLE disease activity index (SLEDAI).Results: There was no significant difference in serum level of ANA (p=0.44), Anti Ds DNA (p= 0.98), C3 (p=0.36) and C4 (p=0.49) in patients before and 12 weeks after vaccination. Serum level of CH50 before and after vaccination was significantly different (p=0.002).Conclusion: Based on this research, we didn't observe any changes in SLEDAI or vaccination complications and considering high risk of pneumonia in SLE patients, vaccination program for this population will be better and beneficial.

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APA: Copy

AGHDASHI, MIR AMIR, SHARIFI, YAGHOOB, & DERAKHSHANFAR, MOSTAFA. (2014). EVALUATION OF INFLUENZA VACCINATION EFFECTS IN DISEASE ACTIVITY AND AUTOANTIBODY GENERATION IN SYSTEMIC LUPUS ERYTHEMATOUS. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 25(1), 51-55. SID. https://sid.ir/paper/64147/en

Vancouver: Copy

AGHDASHI MIR AMIR, SHARIFI YAGHOOB, DERAKHSHANFAR MOSTAFA. EVALUATION OF INFLUENZA VACCINATION EFFECTS IN DISEASE ACTIVITY AND AUTOANTIBODY GENERATION IN SYSTEMIC LUPUS ERYTHEMATOUS. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2014;25(1):51-55. Available from: https://sid.ir/paper/64147/en

IEEE: Copy

MIR AMIR AGHDASHI, YAGHOOB SHARIFI, and MOSTAFA DERAKHSHANFAR, “EVALUATION OF INFLUENZA VACCINATION EFFECTS IN DISEASE ACTIVITY AND AUTOANTIBODY GENERATION IN SYSTEMIC LUPUS ERYTHEMATOUS,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 25, no. 1, pp. 51–55, 2014, [Online]. Available: https://sid.ir/paper/64147/en

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