مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Cites:

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Information Journal Paper

Title

EFFECT OF NIGELLA SATIVA FIXED OIL ON ETHANOL TOXICITY IN RATS

Pages

  1020-1031

Abstract

 Objective(s): This study was planned to appraise the protective effect of NIGELLA SATIVA fixed oil (NSO) against subchronic ethanol induced toxicity in rats.Materials and Methods: Studies were carried out on six groups of six animals each, including control (normal saline, gavage), ethanol (3 g/kg/day, gavage), NSO (0.125, 0.25 and 0.5 ml/Kg/day, IP) plus ethanol and NSO (0.5 ml/Kg/day, IP) groups. Treatments were continued for 4 weeks.Results: According to data, treatment with NSO attenuated ethanol-induced increased levels of malondialdehyde (MDA), tumor necrosis factor a (TNF-a) and interleukin-6 (IL-6), as well as histopathological changes in liver and kidney tissues. Moreover, NSO improved the level of serum liver enzymes (including alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP) and glutathione (GSH) content in liver and kidney tissues in ethanol-treated rats. Western blot analysis and quantitative real time RT-PCR showed that NSO treatment inhibited APOPTOSIS stimulated by ethanol through decreasing the Bax/Bcl-2 ratio (both protein and mRNA levels), cleaved caspase-3, cleaved caspase-8 and cleaved caspase-9 level in liver and kidney.Conclusion: This study showed that NSO may have protective effects against hepatotoxicity and renal toxicity of ethanol by decreasing LIPID PEROXIDATION and inflammation and preventing APOPTOSIS.

Cites

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    APA: Copy

    POURBAKHSH, HAMED, TAGHIABADI, ELAHE, ABNOUS, KHALIL, TIMCHEH HARIRI, ALIREZA, HOSSEINI, SEYED MASOUD, & HOSSEINZADEH, HOSSEIN. (2014). EFFECT OF NIGELLA SATIVA FIXED OIL ON ETHANOL TOXICITY IN RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 17(12), 1020-1031. SID. https://sid.ir/paper/641563/en

    Vancouver: Copy

    POURBAKHSH HAMED, TAGHIABADI ELAHE, ABNOUS KHALIL, TIMCHEH HARIRI ALIREZA, HOSSEINI SEYED MASOUD, HOSSEINZADEH HOSSEIN. EFFECT OF NIGELLA SATIVA FIXED OIL ON ETHANOL TOXICITY IN RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2014;17(12):1020-1031. Available from: https://sid.ir/paper/641563/en

    IEEE: Copy

    HAMED POURBAKHSH, ELAHE TAGHIABADI, KHALIL ABNOUS, ALIREZA TIMCHEH HARIRI, SEYED MASOUD HOSSEINI, and HOSSEIN HOSSEINZADEH, “EFFECT OF NIGELLA SATIVA FIXED OIL ON ETHANOL TOXICITY IN RATS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 17, no. 12, pp. 1020–1031, 2014, [Online]. Available: https://sid.ir/paper/641563/en

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