THE EFFECTS OF NIGELLA SATIVA ON SICKNESS BEHAVIOR INDUCED BY LIPOPOLYSACCHARIDE IN MALE WISTAR RATS

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NOROUZI FATEMEH; ABARESHI AZAM; ANAEIGOUDARI AKBAR; SHAFEI MOHAMMAD NASER; GHOLAMNEZHAD ZAHRA; SAEEDJALALI MOHSEN; MOHEBBATI REZA; HOSSEINI MAHMOUD

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Journal: Avicenna Journal of Phytomedicine Year:2016 | Volume:6 | Issue:1 Page(s): 104-116

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Title

THE EFFECTS OF NIGELLA SATIVA ON SICKNESS BEHAVIOR INDUCED BY LIPOPOLYSACCHARIDE IN MALE WISTAR RATS

Author(s)

Keywords

RAT

LIPOPOLYSACCHARIDE

NIGELLA SATIVA

SICKNESS BEHAVIOR

Abstract

Objective: Neuroimmune factors contribute on the pathogenesis of SICKNESS BEHAVIORs. NIGELLA SATIVA (NS) has anti-inflammatory, anti-anxiety and anti-depressive effects. In the present study, the effect of NS hydro-alcoholic extract on SICKNESS BEHAVIOR induced by LIPOPOLYSACCHARIDE (LPS) was investigated.Materials and Methods: The RATs were divided into five groups (n=10 in each): (1) control (saline), (2) LPS (1 mg/kg, administered two hours before behavioral tests), (3-5) LPS-Nigella sativa 100, 200 and 400 mg/kg (LPS-NS 100, LPS-NS 200 and LPS-NS 400, respectively). Open- field (OF), elevated plus maze (EPM) and forced swimming test (FST) were performed.Results: In OF, LPS reduced the peripheral crossing, peripheral distance, total crossing and total distance compared to control (p<0.01- p<0.001). The central crossing, central distance and central time in LPS-NS 100, LPS-NS200 and LPS-NS 400 groups were higher than LPS (p<0.01- p<0.001). In EPM, LPS decreased the open arm entries, open arm time and closed arm entries while increased the closed time compared to control (p<0.001). Pretreatment by NS extract reversed the effects of LPS (p<0.05- p<0.001). In FST, LPS increased the immobility time while, decreased the climbing and active times compared to control (p<0.05- p<0.001). In LPS-NS 100, LPS-NS 200 and LPS-NS 400 groups the immobility time was less while, the active and climbing times were more than those of LPS (p<0.05- p<0.001).Conclusion: The results of the present study showed that the hydro-alcoholic extract of NS reduced the LPS-induced SICKNESS BEHAVIORs in RATs. Further investigations are required for better understanding the responsible compound (s) and the underlying mechanism (s).

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APA: Copy

NOROUZI, FATEMEH, ABARESHI, AZAM, ANAEIGOUDARI, AKBAR, SHAFEI, MOHAMMAD NASER, GHOLAMNEZHAD, ZAHRA, SAEEDJALALI, MOHSEN, MOHEBBATI, REZA, & HOSSEINI, MAHMOUD. (2016). THE EFFECTS OF NIGELLA SATIVA ON SICKNESS BEHAVIOR INDUCED BY LIPOPOLYSACCHARIDE IN MALE WISTAR RATS. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 6(1), 104-116. SID. https://sid.ir/paper/326310/en

Vancouver: Copy

NOROUZI FATEMEH, ABARESHI AZAM, ANAEIGOUDARI AKBAR, SHAFEI MOHAMMAD NASER, GHOLAMNEZHAD ZAHRA, SAEEDJALALI MOHSEN, MOHEBBATI REZA, HOSSEINI MAHMOUD. THE EFFECTS OF NIGELLA SATIVA ON SICKNESS BEHAVIOR INDUCED BY LIPOPOLYSACCHARIDE IN MALE WISTAR RATS. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2016;6(1):104-116. Available from: https://sid.ir/paper/326310/en

IEEE: Copy

FATEMEH NOROUZI, AZAM ABARESHI, AKBAR ANAEIGOUDARI, MOHAMMAD NASER SHAFEI, ZAHRA GHOLAMNEZHAD, MOHSEN SAEEDJALALI, REZA MOHEBBATI, and MAHMOUD HOSSEINI, “THE EFFECTS OF NIGELLA SATIVA ON SICKNESS BEHAVIOR INDUCED BY LIPOPOLYSACCHARIDE IN MALE WISTAR RATS,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 6, no. 1, pp. 104–116, 2016, [Online]. Available: https://sid.ir/paper/326310/en

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