EFFECTS OF OMEPRAZOLE VS. RANITIDINE ON DUODENAL ULCER HEALING AND PREVENTION OF ULCER RELAPSE OVER 1-YEAR FOLLOW UP: A PROSPECTIVE RANDOMIZED DOUBLE BLIND CLINICAL TRIAL

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BEHROUZIAN R.; HESHMAT RAMIN; AGHDAMI N.; FARHADNIA P.; SALARY SH.

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Journal: Studies in Medical Sciences Year:2001 | Volume:12 | Issue:2 Page(s): 180-187

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Title

EFFECTS OF OMEPRAZOLE VS. RANITIDINE ON DUODENAL ULCER HEALING AND PREVENTION OF ULCER RELAPSE OVER 1-YEAR FOLLOW UP: A PROSPECTIVE RANDOMIZED DOUBLE BLIND CLINICAL TRIAL

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OMEPRAZOLEQ3

RANITIDINEQ3

DUODENAL ULCERQ4

Abstract

Introduction: OMEPRAZOLE and RANITIDINE are the two most widely recommended regimens for the treatment of DUODENAL ULCER (DU).However, no controlled studies with any number of cases and any other similar drugs are available for the reliable comparison of these two regimens in Iran. On the other hand, many factors can affect the treating procedure such as race, habits, culture and socioeconomic status. The aim of this controlled, randomized, prospective study was to compare the effect of these two regimens on DUODENAL ULCER healing and prevention of ulcer relapse over I-year follow up. Materials & Methods: Patients (n=69) with proven DUODENAL ULCER (DU) were randomized to one of the two following regimens: group A, OMEPRAZOLE 20 mg/day for 4 wks and group B, RANITIDINE 300 mg/day for 4 wks. Control endoscopies were performed at the end of second and fourth weeks of treating and when symptoms appeared, (up to 1 yr after treatment).Results: A total of 27 patients in group A and 29 patients in group 13 completed the study. 13 patients, 8 in group A and 5 in group B, did not completed the study and dropped out of it. But all patients tolerated the regimens very well. In subjects who completed the study the healing rate of DU in group A, both at the end of 2nd wk (85.2% compared with 48.3%, p=0.01) and at the end of 4th wk of treatment (100% compared with 75.9%, p= 0.02), were significantly higher than in group B. The symptomatic ulcer relapse during the 1-yr follow up in patients with initially healed ulcers (a total of 36 patients were followed up for 1-yr because of limited time) was 20% in group A and 12.5% in group B (p>0.5).Discussion: The 4-wk treatment with OMEPRAZOLE seems to be more effective than RANITIDINE on DUODENAL ULCER healing. In this manner the 2-wk regimen with OMEPRAZOLE had the same result and no side effect was found during treatment and follow-up periods. However, there was no significant difference in relapse rates among two groups that differs from the results of other studies.

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APA: Copy

BEHROUZIAN, R., HESHMAT, RAMIN, AGHDAMI, N., FARHADNIA, P., & SALARY, SH.. (2001). EFFECTS OF OMEPRAZOLE VS. RANITIDINE ON DUODENAL ULCER HEALING AND PREVENTION OF ULCER RELAPSE OVER 1-YEAR FOLLOW UP: A PROSPECTIVE RANDOMIZED DOUBLE BLIND CLINICAL TRIAL. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 12(2), 180-187. SID. https://sid.ir/paper/64160/en

Vancouver: Copy

BEHROUZIAN R., HESHMAT RAMIN, AGHDAMI N., FARHADNIA P., SALARY SH.. EFFECTS OF OMEPRAZOLE VS. RANITIDINE ON DUODENAL ULCER HEALING AND PREVENTION OF ULCER RELAPSE OVER 1-YEAR FOLLOW UP: A PROSPECTIVE RANDOMIZED DOUBLE BLIND CLINICAL TRIAL. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2001;12(2):180-187. Available from: https://sid.ir/paper/64160/en

IEEE: Copy

R. BEHROUZIAN, RAMIN HESHMAT, N. AGHDAMI, P. FARHADNIA, and SH. SALARY, “EFFECTS OF OMEPRAZOLE VS. RANITIDINE ON DUODENAL ULCER HEALING AND PREVENTION OF ULCER RELAPSE OVER 1-YEAR FOLLOW UP: A PROSPECTIVE RANDOMIZED DOUBLE BLIND CLINICAL TRIAL,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 12, no. 2, pp. 180–187, 2001, [Online]. Available: https://sid.ir/paper/64160/en

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