IMMUNOPAOLOGY OF DRY TYPE CUTANEOUS LEISHMANIASIS, IMMUNOPHENOLYPIC PATTERN AND CYTOKINE PROFILES

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DABIR SH.; MEYMANDI S.; ABDI RAD A.; REZA MIRSHEKARI T.; NIKPOUR H.; MEYMANDI M.

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Journal: Studies in Medical Sciences Year:2001 | Volume:12 | Issue:2 Page(s): 170-179

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Title

IMMUNOPAOLOGY OF DRY TYPE CUTANEOUS LEISHMANIASIS, IMMUNOPHENOLYPIC PATTERN AND CYTOKINE PROFILES

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Keywords

DRY TYPE CUTANEOUS LEISHMANIASISQ4

IMMUNOPHENOTYPINGQ4

CYTOKINEQ4

SKINQ3

IMMUNOHISTOCHEMISTRYQ4

Abstract

Introduction: The precise immune mechanism of leishmanasis has not been introduced, but TCD4+ lymphocytes have a main role in immune response of leishmaniasisMethods & Materials: In our research we obtain SKIN biopsies from twelve patients with dry type cutaneous, leishmaniasis After freezing, immuoperoxidase staining for IMMUNOPHENOTYPING evalution (CD4, CD8, CD14 CD1a CD54, CD56 CD19, HLA-DR) and their CYTOKINE seretions (IL4, IL10 IL12 INFy) from immune inflammatory cells was done. The patients classified based on histopathology classification by Dr. Azadeh into three groups:1- Acute 2- Non-heald chronic3- Lupoid recidivansResults: In this study we hypothesize that Th1 based on INFy and lL12 seretion and CD4+ marker is predominant in acute form. Th2 based on lL4 and lL10 Secretion and CD4+ marker is predominant in non-heald chronic lesion and Th1/Th2 imbalance pattern in lupoid recidivans.Discussion: We determine CYTOKINE profile of the immune inflammatory cells and compare various kinds of CYTOKINEs released by them in these three groups of cutaneous leishmaniasis.

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APA: Copy

DABIR, SH., MEYMANDI, S., ABDI RAD, A., REZA MIRSHEKARI, T., NIKPOUR, H., & MEYMANDI, M.. (2001). IMMUNOPAOLOGY OF DRY TYPE CUTANEOUS LEISHMANIASIS, IMMUNOPHENOLYPIC PATTERN AND CYTOKINE PROFILES. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 12(2), 170-179. SID. https://sid.ir/paper/64169/en

Vancouver: Copy

DABIR SH., MEYMANDI S., ABDI RAD A., REZA MIRSHEKARI T., NIKPOUR H., MEYMANDI M.. IMMUNOPAOLOGY OF DRY TYPE CUTANEOUS LEISHMANIASIS, IMMUNOPHENOLYPIC PATTERN AND CYTOKINE PROFILES. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2001;12(2):170-179. Available from: https://sid.ir/paper/64169/en

IEEE: Copy

SH. DABIR, S. MEYMANDI, A. ABDI RAD, T. REZA MIRSHEKARI, H. NIKPOUR, and M. MEYMANDI, “IMMUNOPAOLOGY OF DRY TYPE CUTANEOUS LEISHMANIASIS, IMMUNOPHENOLYPIC PATTERN AND CYTOKINE PROFILES,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 12, no. 2, pp. 170–179, 2001, [Online]. Available: https://sid.ir/paper/64169/en

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