EXPRESSION OF ACRA AND ACRB GENES IN ESHERICHIA COLI MUTANTS WITH OR WITHOUT MARR OR ACRR MUTATIONS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

POURAHMAD JAKTAJI RAZIEH; JAZAYERI NASIM

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2013 | Volume:16 | Issue:12 Page(s): 1254-1258

Download Full-Text

View:

366

Download:

206

Cites:

Information Journal Paper

Title

EXPRESSION OF ACRA AND ACRB GENES IN ESHERICHIA COLI MUTANTS WITH OR WITHOUT MARR OR ACRR MUTATIONS

Author(s)

POURAHMAD JAKTAJI RAZIEH | JAZAYERI NASIM | Issue Writer Certificate

Keywords

ACRAB OPERON ACRR MARR MULTIPLE ANTIBIOTIC RESISTANCE

Abstract

Objective (s): The major antibiotic efflux pump of Esherichia coli is AcrAB-TolC. The first part of the pump, AcrAB, is encoded by acrAB operon. The expression of this operon can be kept elevated by overexpression of an activator, MarA following inactivation of MarR and AcrR repressors due to mutation in encoding genes, marR and acrR, respectively. The aims of this research were to use E. coli mutants with or without mutation in marR to search for the presence of possible mutation in acrR and to quantify the expression of acrAB.Materials and Methods: The DNA binding region of acrR gene in these mutants were amplified by PCR and sequenced. The relative expression of acrA and acrB were determined by real time PCR.Results: Results showed that W26 and C14 had the same mutation in acrR, but none of the mutants overexpressed acrA and acrB in comparison with wild type strain.Conclusions: The effect of marR or acrR mutation on acrAB overexpression is dependent on levels of resistance to tetracycline and ciprofloxacin.

Cites

No record.

References

No record.

Cite

APA: Copy

POURAHMAD JAKTAJI, RAZIEH, & JAZAYERI, NASIM. (2013). EXPRESSION OF ACRA AND ACRB GENES IN ESHERICHIA COLI MUTANTS WITH OR WITHOUT MARR OR ACRR MUTATIONS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 16(12), 1254-1258. SID. https://sid.ir/paper/641924/en

Vancouver: Copy

POURAHMAD JAKTAJI RAZIEH, JAZAYERI NASIM. EXPRESSION OF ACRA AND ACRB GENES IN ESHERICHIA COLI MUTANTS WITH OR WITHOUT MARR OR ACRR MUTATIONS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2013;16(12):1254-1258. Available from: https://sid.ir/paper/641924/en

IEEE: Copy

RAZIEH POURAHMAD JAKTAJI, and NASIM JAZAYERI, “EXPRESSION OF ACRA AND ACRB GENES IN ESHERICHIA COLI MUTANTS WITH OR WITHOUT MARR OR ACRR MUTATIONS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 16, no. 12, pp. 1254–1258, 2013, [Online]. Available: https://sid.ir/paper/641924/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops