THE EFFECT OF CYCLOSPORIN A ON MAMMARY GLANDS OF RATS

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SHIRPOUR A.; TAGHIZADEH AFSHARI A.; FARSHID A.A.; ESKANDARI M.

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Journal: Studies in Medical Sciences Year:2002 | Volume:13 | Issue:2 Page(s): 102-108

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Title

THE EFFECT OF CYCLOSPORIN A ON MAMMARY GLANDS OF RATS

Author(s)

SHIRPOUR A. | TAGHIZADEH AFSHARI A. | FARSHID A.A. | ESKANDARI M. | Issue Writer Certificate

Keywords

CYCLOSPORN AQ4

HYPERPLASIAQ4

GRAFTQ3

MAMMARY GLANDQ4

Abstract

Introduction: Cyclosporin A is one the immunosuppresive drugs which is applied to decrease the rejection rate of GRAFT after surgical operations, and has numerous side effects.Materials & Methods: In this study, the effect of cyclosporin A on MAMMARY GLANDs of rats was studied. Cyclosporin A was added daily on 12.5g of their feed at dose rate of 20mg/kg body weight for a period of 45 days for 12 experimental rats. Twelve control rats were given only the commercial feed. At end of the experiment, the animals were euthanised and autopsy was performed. Results: No gross or microscopic changes seen in the mammary tissues of control rats. In the experimental animals 3 cases showed gross masses in the MAMMARY GLANDs which histological studied. There was HYPERPLASIA of the epithelium in mammary ducts with increase fibrous tissue around them. Discussion: This study may bring to light the hyperplastic effect of cyclosporine A on MAMMARY GLAND of rats.

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APA: Copy

SHIRPOUR, A., TAGHIZADEH AFSHARI, A., FARSHID, A.A., & ESKANDARI, M.. (2002). THE EFFECT OF CYCLOSPORIN A ON MAMMARY GLANDS OF RATS. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 13(2), 102-108. SID. https://sid.ir/paper/64229/en

Vancouver: Copy

SHIRPOUR A., TAGHIZADEH AFSHARI A., FARSHID A.A., ESKANDARI M.. THE EFFECT OF CYCLOSPORIN A ON MAMMARY GLANDS OF RATS. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2002;13(2):102-108. Available from: https://sid.ir/paper/64229/en

IEEE: Copy

A. SHIRPOUR, A. TAGHIZADEH AFSHARI, A.A. FARSHID, and M. ESKANDARI, “THE EFFECT OF CYCLOSPORIN A ON MAMMARY GLANDS OF RATS,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 13, no. 2, pp. 102–108, 2002, [Online]. Available: https://sid.ir/paper/64229/en

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