BEHAVIORAL (FUNCTION INDEX) AND HISTOPATHOLOGICAL STUDY OF HISTIDINE EFFECT ON REGENERATION OF EXPERIMENTAL CRUSHED SCIATIC NERVE OF RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

AMNIATTALAB AMIR; TAMADDONFARD ESMAEEL; CHERAGHIAN SIAMAK

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Studies in Medical Sciences Year:2010 | Volume:21 | Issue:2 Page(s): 103-111

Download Full-Text

Persian Verion

View:

1,097

Download:

Cites:

Information Journal Paper

Title

BEHAVIORAL (FUNCTION INDEX) AND HISTOPATHOLOGICAL STUDY OF HISTIDINE EFFECT ON REGENERATION OF EXPERIMENTAL CRUSHED SCIATIC NERVE OF RATS

Author(s)

AMNIATTALAB AMIR | TAMADDONFARD ESMAEEL | CHERAGHIAN SIAMAK | Issue Writer Certificate

Keywords

HISTIDINEQ3

EXPERIMENTAL CRUSHQ3

SCIATIC NERVEQ3

BEHAVIORAL STUDYQ3

HISTOPATHOLOGYQ3

RATQ3

Abstract

Background and Aims: HISTIDINE is an essential amino acid. In this study, both HISTIDINE effect on nerve function index and histopathological changes in nerve regeneration process were evaluated in RATs with crushed SCIATIC NERVE.Materials and Methods: 57 RATs were used to evaluate the SCIATIC NERVE function index and to study the histopathological SCIATIC NERVE sections stained with three methods. Effective factors in nerve regeneration like number of Schwann cells nucleus and myelinated nerve fibers were studied.Results: There was a significant reduce in sciatic function index (p<0.05) a significant reduce in the case groups and a significant increase in numbers of Schwann cells nucleus (p<0.05) in HISTIDINE 400 mg/kg group compared with the control group (normal saline). In HISTIDINE 400 mg/kg group, the numbers of myelinated nerve fibers on 42nd day increased significantly in comparision with days 14 and 28 (p<0.05).Conclusion: It is revealed that in crush injuries, HISTIDINE in 400 mg/kg dosage caused normal recurrence of SCIATIC NERVE index. Recent researches have shown that during wallerian degeneration period the proliferation of Schwann cells is not necessary for regeneration and remyelination of peripheral nerves. But the increase of myelinated nerve fibers in HISTIDINE 400 mg/kg group, on day 42 indicates the useful effect of HISTIDINE in peripheral nerve regeneration.

Cites

No record.

References

No record.

Cite

APA: Copy

AMNIATTALAB, AMIR, TAMADDONFARD, ESMAEEL, & CHERAGHIAN, SIAMAK. (2010). BEHAVIORAL (FUNCTION INDEX) AND HISTOPATHOLOGICAL STUDY OF HISTIDINE EFFECT ON REGENERATION OF EXPERIMENTAL CRUSHED SCIATIC NERVE OF RATS. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 21(2), 103-111. SID. https://sid.ir/paper/64248/en

Vancouver: Copy

AMNIATTALAB AMIR, TAMADDONFARD ESMAEEL, CHERAGHIAN SIAMAK. BEHAVIORAL (FUNCTION INDEX) AND HISTOPATHOLOGICAL STUDY OF HISTIDINE EFFECT ON REGENERATION OF EXPERIMENTAL CRUSHED SCIATIC NERVE OF RATS. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2010;21(2):103-111. Available from: https://sid.ir/paper/64248/en

IEEE: Copy

AMIR AMNIATTALAB, ESMAEEL TAMADDONFARD, and SIAMAK CHERAGHIAN, “BEHAVIORAL (FUNCTION INDEX) AND HISTOPATHOLOGICAL STUDY OF HISTIDINE EFFECT ON REGENERATION OF EXPERIMENTAL CRUSHED SCIATIC NERVE OF RATS,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 21, no. 2, pp. 103–111, 2010, [Online]. Available: https://sid.ir/paper/64248/en

Related Journal Papers