A COMARATIVE STUDY OF THE EUTIC EFFICACY OF FLUOXETINE AND CLOMIPRAMINE IN OBSESSIVE-COMPULSIVE DISORDER

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POURAFKARY N.; NABDEL Y.; DADASHZADEH H.

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Journal: Studies in Medical Sciences Year:2004 | Volume:14 | Issue:4 Page(s): 286-294

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Title

A COMARATIVE STUDY OF THE EUTIC EFFICACY OF FLUOXETINE AND CLOMIPRAMINE IN OBSESSIVE-COMPULSIVE DISORDER

Author(s)

POURAFKARY N. | NABDEL Y. | DADASHZADEH H. | Issue Writer Certificate

Keywords

OBSESSIVE - COMPULSIVE DISORDERQ4

FLUOXETINEQ4

CLOMIPRAMINEQ4

Abstract

Background & Aim: CLOMIPRAMINE, a tricyclic antidepressant agent, and fluoxetin, a selective serotonin reuptake inhibitor, have been shown to be effective in treatment of obsessive-compulsive disorders. This study was carried out to compare the efficacy of FLUOXETINE and CLOMIPRAMINE in treatment of 110 obsessive - compulsive outpatients. Materials and Methods: 110 obsessive-compulsive outpatients were selected randomly from two psychiatric clinics in Tabriz. At the beginning, patients were devided in to two groups randomly, and in the second phase of the study, they were assigned to three groups, by a sequential sampling. The efficacy of FLUOXETINE and CLOMIPRAMINE was compared in first and second groups. In the third and fourth groups the patients resistant to each drug were treated with the other drug. In the last phase patient to both drugs were treated by combination of two agents (5 th group). Results: The results showed relative superiority of FLUOXETINE to clomipramin in some patients with obsessire-compulsive disorder (p<0.01 and p<0.05), but in some cases the difference was not significant. Discussion: Considering the results of the study, FLUOXETINE is a first line probably therapeutic agent for obsessive-compulsive disorder and probalily an appropriate pharmacological approach in treating obsessive-compulsive patients in our country.

Cites

A META-ANALYSIS ON THE EFFECTIVENESS OF DRUG THERAPY IN IMPROVING OBSESSIVE-COMPULSIVE DISORDER SYMPTOMS

References

برسی اثرات سه دارون در درمان بیماران وسواس فکری و عملی

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APA: Copy

POURAFKARY, N., NABDEL, Y., & DADASHZADEH, H.. (2004). A COMARATIVE STUDY OF THE EUTIC EFFICACY OF FLUOXETINE AND CLOMIPRAMINE IN OBSESSIVE-COMPULSIVE DISORDER . STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 14(4), 286-294. SID. https://sid.ir/paper/64315/en

Vancouver: Copy

POURAFKARY N., NABDEL Y., DADASHZADEH H.. A COMARATIVE STUDY OF THE EUTIC EFFICACY OF FLUOXETINE AND CLOMIPRAMINE IN OBSESSIVE-COMPULSIVE DISORDER . STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2004;14(4):286-294. Available from: https://sid.ir/paper/64315/en

IEEE: Copy

N. POURAFKARY, Y. NABDEL, and H. DADASHZADEH, “A COMARATIVE STUDY OF THE EUTIC EFFICACY OF FLUOXETINE AND CLOMIPRAMINE IN OBSESSIVE-COMPULSIVE DISORDER ,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 14, no. 4, pp. 286–294, 2004, [Online]. Available: https://sid.ir/paper/64315/en

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