SURVEY OF CORRELATION BETWEEN SERUM CERULOPLASMIN LEVEL AND CORONARY ARTERY DISEASE

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KHADEM VATANI KAMAL; KHADEM ANSARI MOHAMMAD HASAN; OLOOFI SOLMAZ; SHAKIBI ALI; Rostamzadeh Alireza; ASKARI BEHNAM; MEHRPOOYA MARYAM; HAJAHMADIPOOR RAFSANJANI MOJJGHAN; SEYED MOHAMMADZAD MIR HOSEIN

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Journal: Studies in Medical Sciences Year:2016 | Volume:26 | Issue:11 Page(s): 984-992

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Title

SURVEY OF CORRELATION BETWEEN SERUM CERULOPLASMIN LEVEL AND CORONARY ARTERY DISEASE

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Keywords

CERULOPLASMINQ3

CORONARY ARTERY DISEASEQ2

ATHEROSCLEROSISQ2

Abstract

Background & Aims: Over the last decade, cardiovascular disease (CVD) has become the single largest cause of death worldwide including all developing regions. The CORONARY ARTERY DISEASE (CAD) is the most lethal form of CVD. CERULOPLASMIN is a ferroxidase enzyme with two paradoxically oxidative and antioxidative performances. Some studies show that CERULOPLASMIN give rise to ATHEROSCLEROSIS by oxidative effect on low density lipoprotein (LDL).Materials & Methods: This study was done in Urmia Seyed-ol Shohada Hospital. The serum levels of CERULOPLASMIN were measured in 43 consecutive CAD patients (more than 75% stenosis at least in one coronary arteries by selective coronary angiography) and 43 consecutive control subjects (normal epicardial coronary arteries by selective coronary angiography). Exclusion criteria were lymphoma, pregnancy, oral contraceptive drugs, rheumatoid arthritis, Alzheimer's disease, heart failure (LVEF<40%), diabetes mellitus, heavy smokers, obsessive disorders, schizophrenia, dyslipidemia, and hypertension. CAD patients and normal group were matched for hypertension and dyslipidemia.Results: There wasn’t significant statistical difference in serum CERULOPLASMIN level between CAD patients (298±115mg/L) and control subjects (281±81mg/L).There wasn’t significant gender difference in serum CERULOPLASMIN level.Conclusion: The result of the present study doesn’t support the hypothesis that a high serum CERULOPLASMIN level is a risk factor for CORONARY ARTERY DISEASE. If we exclude major CAD risk factors and effective factors on serum CERULOPLASMIN level, it can be stated that a high serum CERULOPLASMIN level is not an independent risk factor for atherosclerotic CAD.

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APA: Copy

KHADEM VATANI, KAMAL, KHADEM ANSARI, MOHAMMAD HASAN, OLOOFI, SOLMAZ, SHAKIBI, ALI, Rostamzadeh, Alireza, ASKARI, BEHNAM, MEHRPOOYA, MARYAM, HAJAHMADIPOOR RAFSANJANI, MOJJGHAN, & SEYED MOHAMMADZAD, MIR HOSEIN. (2016). SURVEY OF CORRELATION BETWEEN SERUM CERULOPLASMIN LEVEL AND CORONARY ARTERY DISEASE. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 26(11), 984-992. SID. https://sid.ir/paper/64346/en

Vancouver: Copy

KHADEM VATANI KAMAL, KHADEM ANSARI MOHAMMAD HASAN, OLOOFI SOLMAZ, SHAKIBI ALI, Rostamzadeh Alireza, ASKARI BEHNAM, MEHRPOOYA MARYAM, HAJAHMADIPOOR RAFSANJANI MOJJGHAN, SEYED MOHAMMADZAD MIR HOSEIN. SURVEY OF CORRELATION BETWEEN SERUM CERULOPLASMIN LEVEL AND CORONARY ARTERY DISEASE. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2016;26(11):984-992. Available from: https://sid.ir/paper/64346/en

IEEE: Copy

KAMAL KHADEM VATANI, MOHAMMAD HASAN KHADEM ANSARI, SOLMAZ OLOOFI, ALI SHAKIBI, Alireza Rostamzadeh, BEHNAM ASKARI, MARYAM MEHRPOOYA, MOJJGHAN HAJAHMADIPOOR RAFSANJANI, and MIR HOSEIN SEYED MOHAMMADZAD, “SURVEY OF CORRELATION BETWEEN SERUM CERULOPLASMIN LEVEL AND CORONARY ARTERY DISEASE,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 26, no. 11, pp. 984–992, 2016, [Online]. Available: https://sid.ir/paper/64346/en

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