EVALUATION OF ALPHA- AMYLASE INHIBITION BY URTICA DIOICA AND JUGLANS REGIA EXTRACTS; SHORT COMMUNICATION

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RAHIMZADEH MAHSA; JAHANSHAHI SAMANEH; MOEIN SOHEILA; MOEIN MAHMOOD REZA

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Journal Paper

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Journal: Iranian Journal of Basic Medical Sciences Year:2014 | Volume:17 | Issue:6 Page(s): 465-469

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Title

EVALUATION OF ALPHA- AMYLASE INHIBITION BY URTICA DIOICA AND JUGLANS REGIA EXTRACTS; SHORT COMMUNICATION

Author(s)

RAHIMZADEH MAHSA | JAHANSHAHI SAMANEH | MOEIN SOHEILA | MOEIN MAHMOOD REZA | Issue Writer Certificate

Keywords

AMYLASE INHIBITION

DIABETES

PLANT EXTRACT

Abstract

Objective(s): One strategy for the treatment of DIABETES is inhibition of pancreatic a- amylase. Plants contains different chemical constituents with potential for inhibition of a-amylase and hence maybe used as therapeutic.Materials and Methods: Urtica dioica and Juglans regia Linn were tested for a-AMYLASE INHIBITION. Different concentrations of leaf aqueous extracts were incubated with enzyme substrate solution and the activity of enzyme was measured. For determination of the type of inhibition, Dixon plot was depicted. Acarbose was used as the standard inhibitor.Results: Both PLANT EXTRACTs showed time and concentration dependent inhibition of a-amylase. 60% inhibition was seen with 2 mg/ml of U. dioica and 0.4 mg/ml of J. regia aqueous extract. Dixon plots revealed the type of a-AMYLASE INHIBITION by these two extracts as competitive inhibition.Conclusion: Determination of the type of a-AMYLASE INHIBITION by these PLANT EXTRACTs could provide by successful use of plant chemicals as drug targets.

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APA: Copy

RAHIMZADEH, MAHSA, JAHANSHAHI, SAMANEH, MOEIN, SOHEILA, & MOEIN, MAHMOOD REZA. (2014). EVALUATION OF ALPHA- AMYLASE INHIBITION BY URTICA DIOICA AND JUGLANS REGIA EXTRACTS; SHORT COMMUNICATION. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 17(6), 465-469. SID. https://sid.ir/paper/643481/en

Vancouver: Copy

RAHIMZADEH MAHSA, JAHANSHAHI SAMANEH, MOEIN SOHEILA, MOEIN MAHMOOD REZA. EVALUATION OF ALPHA- AMYLASE INHIBITION BY URTICA DIOICA AND JUGLANS REGIA EXTRACTS; SHORT COMMUNICATION. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2014;17(6):465-469. Available from: https://sid.ir/paper/643481/en

IEEE: Copy

MAHSA RAHIMZADEH, SAMANEH JAHANSHAHI, SOHEILA MOEIN, and MAHMOOD REZA MOEIN, “EVALUATION OF ALPHA- AMYLASE INHIBITION BY URTICA DIOICA AND JUGLANS REGIA EXTRACTS; SHORT COMMUNICATION,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 17, no. 6, pp. 465–469, 2014, [Online]. Available: https://sid.ir/paper/643481/en

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