SERUM URIC ACID LEVEL AND ITS ASSOCIATION WITH CARDIOMETABOLIC RISK FACTORS IN PREDIABETIC SUBJECTS

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IRAJ BIJAN; FEIZI AWAT; ABDAR ESFAHANI MORTEZA; HEIDARI BENI MOTAHAR; ZARE MARYAM; AMINI MASOUD; PARSA FATEMEH

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Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2014 | Volume:19 | Issue:3 Page(s): 262-267

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Title

SERUM URIC ACID LEVEL AND ITS ASSOCIATION WITH CARDIOMETABOLIC RISK FACTORS IN PREDIABETIC SUBJECTS

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Keywords

CARDIOMETABOLIC

GLUCOSE TOLERANCE

PREDIABETIC

URIC ACID

Abstract

Background: Excess serum URIC ACID (UA) accumulation can lead to various diseases. Increasing evidences reveal that UA may have a key role in the pathogenesis of metabolic syndrome. Little is known about the associations of UA levels with CARDIOMETABOLIC risk factors in PREDIABETIC individuals. This study was designed to evaluate the association between UA and CARDIOMETABOLIC risk factors in PREDIABETIC subjects with family history of diabetes compared with those with normal GLUCOSE TOLERANCE (NGT).Materials and Methods: In a cross-sectional setting, a sample containing 643 (302 PREDIABETIC subjects and 341 normal) of the first-degree relatives of diabetic patients aged 35-55-years old were investigated. Samples were assessed in PREDIABETIC and normal groups using GLUCOSE TOLERANCE categories. Prediabetes was defined based on American Diabetes Association (ADA) criteria. Body weight and height, systolic and diastolic blood pressure (SBP and DBP), UA, creatinine (Cr), albumin (Alb), fasting blood glucose (FBG), hemoglobin A1c (HbA1c), and lipid profiles were measured and compared between two groups.Results: PREDIABETIC persons were older and obese than normal persons. Also, PREDIABETIC persons (5.2±1.3 mg/dl) had significantly higher UA than normal persons (4.9±1.4 mg/dl) (P<0.05). FBG after 0, 30, 60, and 120 min in PREDIABETIC were higher than normal persons (P<0.001). With respect to metabolic parameters, the patients in the higher UA quartiles exhibited higher levels of body mass index (BMI), SBP, FBG and triglycerides (TG). The higher quartiles of UA tended to be associated with higher BMI and higher total cholesterol (TC) in females PREDIABETIC persons. Based on logistic regression analysis in different models, UA was positively (odds ratio (OR) >1, P<0.05) associated with GLUCOSE TOLERANCE categories. This association remained statistically significant after adjusting the effects of age and BMI. Also, the association between GLUCOSE TOLERANCE categories and UA were positively significant in both genders.Conclusion: High UA level was associated with some cardio metabolic risk factors in PREDIABETIC individuals compared with normal person. UA level was also a significant predictor for prediabetes condition.

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APA: Copy

IRAJ, BIJAN, FEIZI, AWAT, ABDAR ESFAHANI, MORTEZA, HEIDARI BENI, MOTAHAR, ZARE, MARYAM, AMINI, MASOUD, & PARSA, FATEMEH. (2014). SERUM URIC ACID LEVEL AND ITS ASSOCIATION WITH CARDIOMETABOLIC RISK FACTORS IN PREDIABETIC SUBJECTS. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 19(3), 262-267. SID. https://sid.ir/paper/644542/en

Vancouver: Copy

IRAJ BIJAN, FEIZI AWAT, ABDAR ESFAHANI MORTEZA, HEIDARI BENI MOTAHAR, ZARE MARYAM, AMINI MASOUD, PARSA FATEMEH. SERUM URIC ACID LEVEL AND ITS ASSOCIATION WITH CARDIOMETABOLIC RISK FACTORS IN PREDIABETIC SUBJECTS. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2014;19(3):262-267. Available from: https://sid.ir/paper/644542/en

IEEE: Copy

BIJAN IRAJ, AWAT FEIZI, MORTEZA ABDAR ESFAHANI, MOTAHAR HEIDARI BENI, MARYAM ZARE, MASOUD AMINI, and FATEMEH PARSA, “SERUM URIC ACID LEVEL AND ITS ASSOCIATION WITH CARDIOMETABOLIC RISK FACTORS IN PREDIABETIC SUBJECTS,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 19, no. 3, pp. 262–267, 2014, [Online]. Available: https://sid.ir/paper/644542/en

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