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Information Journal Paper

Title

MILD HYPOTHERMIA REDUCES EXPRESSION OF FAS/FASL AND MMP-3 AFTER CEREBRAL ISCHEMIA-REPERFUSION IN RATS

Pages

  454-459

Abstract

 Objective(s): To investigate the effects of local mild HYPOTHERMIA on the expression of FAS, FASL and MMP-3 after cerebral ischemia-reperfusion in rats.Materials and Methods: Male Wistar rats were divided into sham-operated group (Sham), normothermia group (NT), and HYPOTHERMIA group (HT). MCAO/R model was established by Longa’s method, and reperfusion was allowed after 2 hr occlusion. Mild HYPOTHERMIA (33±0.5oC) for 6 hr was initiated at the start of reperfusion. Immunohistochemistry was performed to determine expression FAS, FASL, and MMP-3.Results: Infarct volume was reduced in the HYPOTHERMIA group (18.43±4.23%) compared with the normothermia group (24.76±5.76%) (P<0.05). In mild HYPOTHERMIA group, numbers of FAS-positive and MMP-3 positive cells were significantly less than those of normothermia group (P<0.05). Neurological functional scores of mild HYPOTHERMIA were significantly improved (P<0.05).Conclusion: Mild HYPOTHERMIA decreases infarct volume after cerebral ischemia-reperfusion, reduces FAS and MMP-3 expression, but increases FASL in cerebral ischemia-reperfusion rats.

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    APA: Copy

    ZHAO, JINGKUN, DUAN, SHURONG, ZHOU, JINXIA, SUN, RUIHONG, ZHANG, LIMING, & WANG, DESHENG. (2014). MILD HYPOTHERMIA REDUCES EXPRESSION OF FAS/FASL AND MMP-3 AFTER CEREBRAL ISCHEMIA-REPERFUSION IN RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 17(6), 454-459. SID. https://sid.ir/paper/645736/en

    Vancouver: Copy

    ZHAO JINGKUN, DUAN SHURONG, ZHOU JINXIA, SUN RUIHONG, ZHANG LIMING, WANG DESHENG. MILD HYPOTHERMIA REDUCES EXPRESSION OF FAS/FASL AND MMP-3 AFTER CEREBRAL ISCHEMIA-REPERFUSION IN RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2014;17(6):454-459. Available from: https://sid.ir/paper/645736/en

    IEEE: Copy

    JINGKUN ZHAO, SHURONG DUAN, JINXIA ZHOU, RUIHONG SUN, LIMING ZHANG, and DESHENG WANG, “MILD HYPOTHERMIA REDUCES EXPRESSION OF FAS/FASL AND MMP-3 AFTER CEREBRAL ISCHEMIA-REPERFUSION IN RATS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 17, no. 6, pp. 454–459, 2014, [Online]. Available: https://sid.ir/paper/645736/en

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