THE PRO-APOPTOTIC EFFECT OF ALLICIN ON HUMAN COLON ADENOCARCINOMA CELL LINE HT29

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

AZIZZADEH DELSHAD ALIREZA; HOSSEIN GHAINI MOHAMMAD; HESHMATI MARJAN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF PATHOLOGY (IJP) Year:2014 | Volume:9 | Issue:2 Page(s): 124-132

Download Full-Text

View:

266

Download:

118

Cites:

Information Journal Paper

Title

THE PRO-APOPTOTIC EFFECT OF ALLICIN ON HUMAN COLON ADENOCARCINOMA CELL LINE HT29

Author(s)

AZIZZADEH DELSHAD ALIREZA | HOSSEIN GHAINI MOHAMMAD | HESHMATI MARJAN | Issue Writer Certificate

Keywords

ALLICIN

CELL LINE

APOPTOSIS

COLON

ADENOCARCINOMA

Abstract

Background and Objective: The management of apoptotic cell death has been considered as a putative therapeutic strategy for cancer treatment. In the present study we investigated the putative pro-apoptotic effect of ALLICIN, the main garlic organosulfur component with repeatedly claimed chemopreventive potency, on the human ADENOCARCINOMA CELL LINE HT29 as an APOPTOSIS resistant CELL LINE, in vitro.Materials and Methods: The HT29 cells were incubated with different concentrations of ALLICIN (0-40mg/ml) and for different time periods (6-48h) to investigate its effect on cell proliferation and apoptotic cell death.Results: Five and 10mg/ml ALLICIN could induce a significant cell death only after 12h, whereas concentrations of 20 and 40mg/ml resulted in a significant cell loss as soon as 6h. The results of the TUNEL assay, presented as percentage of apoptotic cells to total cell loss, indicated that concentrations ³5μg/ml significantly increased the apoptotic features in time periods 6-24h, but after 48h no significant changes could be detected. The ratio of the sum of the apoptotic features of the four studied time points to the total cell loss calculated after 48h was about 0.5.Conclusion: ALLICIN can induce APOPTOSIS in a concentration- and time-dependent manner with most considerable effects achieved at 24h and by concentrations higher than 10mg/ml.

Cites

No record.

References

No record.

Cite

APA: Copy

AZIZZADEH DELSHAD, ALIREZA, HOSSEIN GHAINI, MOHAMMAD, & HESHMATI, MARJAN. (2014). THE PRO-APOPTOTIC EFFECT OF ALLICIN ON HUMAN COLON ADENOCARCINOMA CELL LINE HT29. IRANIAN JOURNAL OF PATHOLOGY (IJP), 9(2), 124-132. SID. https://sid.ir/paper/647081/en

Vancouver: Copy

AZIZZADEH DELSHAD ALIREZA, HOSSEIN GHAINI MOHAMMAD, HESHMATI MARJAN. THE PRO-APOPTOTIC EFFECT OF ALLICIN ON HUMAN COLON ADENOCARCINOMA CELL LINE HT29. IRANIAN JOURNAL OF PATHOLOGY (IJP)[Internet]. 2014;9(2):124-132. Available from: https://sid.ir/paper/647081/en

IEEE: Copy

ALIREZA AZIZZADEH DELSHAD, MOHAMMAD HOSSEIN GHAINI, and MARJAN HESHMATI, “THE PRO-APOPTOTIC EFFECT OF ALLICIN ON HUMAN COLON ADENOCARCINOMA CELL LINE HT29,” IRANIAN JOURNAL OF PATHOLOGY (IJP), vol. 9, no. 2, pp. 124–132, 2014, [Online]. Available: https://sid.ir/paper/647081/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops