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Information Journal Paper

Title

ONE-SHOT, LOW-DOSAGE INTRATYMPANIC GENTAMICIN FOR MENIERE’S DISEASE: CLINICAL, POSTUROGRAPHIC AND VESTIBULAR TEST FINDINGS

Pages

  33-39

Abstract

 Background: MENIERE’S DISEASE has been remained as a difficult therapeutic challenge. The present study aimed to determine the effects of one-shot low-dosage intratympanic GENTAMICIN on vertigo control, auditory outcomes and findings of computerized DYNAMIC POSTUROGRAPHY and VESTIBULAR EVOKED MYOGENIC POTENTIALS in patients with unilateral MENIERE’S DISEASE.Methods: In a prospective clinical study, 30 patients with unilateral MENIERE’S DISEASE were treated with one-shot intratympanic injection of 20 milligrams GENTAMICIN. Main outcome measures included clinical, audiometric, postural and vestibular outcomes evaluated 1 and 9 months after the treatment.Results: Mean vertigo attacks frequency, pure tone average threshold and functional level scale significantly decreased after the treatment (P<0.05). Effective vertigo control (class A and B) obtained in 95.8% of the patients. In total, 75% of patients reported decrease in both aural fullness and tinnitus. VESTIBULAR EVOKED MYOGENIC POTENTIALS became absent in all the patients but four of them. Posturographic scores were improved after the treatment.Conclusion: One-shot low-dosage GENTAMICIN was effective in controlling vertigo attacks in MENIERE’S DISEASE and has useful effects on aural fullness and tinnitus of patients as well. Postural and vestibular tests only have adjunctive role for monitoring therapeutic responses in intratympanic GENTAMICIN-therapy.

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    APA: Copy

    DANESHI, AHMAD, JAHANDIDEH, HESAM, POUSTI, SEYED BEHZAD, & MOHAMMADI, SHABAHANG. (2014). ONE-SHOT, LOW-DOSAGE INTRATYMPANIC GENTAMICIN FOR MENIERE’S DISEASE: CLINICAL, POSTUROGRAPHIC AND VESTIBULAR TEST FINDINGS. CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY), 13(1), 33-39. SID. https://sid.ir/paper/648133/en

    Vancouver: Copy

    DANESHI AHMAD, JAHANDIDEH HESAM, POUSTI SEYED BEHZAD, MOHAMMADI SHABAHANG. ONE-SHOT, LOW-DOSAGE INTRATYMPANIC GENTAMICIN FOR MENIERE’S DISEASE: CLINICAL, POSTUROGRAPHIC AND VESTIBULAR TEST FINDINGS. CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY)[Internet]. 2014;13(1):33-39. Available from: https://sid.ir/paper/648133/en

    IEEE: Copy

    AHMAD DANESHI, HESAM JAHANDIDEH, SEYED BEHZAD POUSTI, and SHABAHANG MOHAMMADI, “ONE-SHOT, LOW-DOSAGE INTRATYMPANIC GENTAMICIN FOR MENIERE’S DISEASE: CLINICAL, POSTUROGRAPHIC AND VESTIBULAR TEST FINDINGS,” CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY), vol. 13, no. 1, pp. 33–39, 2014, [Online]. Available: https://sid.ir/paper/648133/en

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