ART OUTCOMES IN GNRH ANTAGONIST PROTOCOL (FLEXIBLE) AND LONG GNRH AGONIST PROTOCOL DURING EARLY FOLLICULAR PHASE IN PATIENTS WITH POLYCYSTIC OVARY SYNDROME: A RANDOMIZED CLINICAL TRIAL

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MOKHTAR SARA; SADEGHI MOHAMMAD REZA; AKHONDI MOHAMMAD MEHDI; ZAFARDOUST SIMIN; BADENUSH BITA; FATEMI FARNAZ; NAZARI FATTANE; KAMALI KOOROSH; MOHAMMADZADEH AFSANEH

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Journal Paper

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Journal: Journal of Reproduction & Infertility Year:2015 | Volume:16 | Issue:3 Page(s): 148-154

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Title

ART OUTCOMES IN GNRH ANTAGONIST PROTOCOL (FLEXIBLE) AND LONG GNRH AGONIST PROTOCOL DURING EARLY FOLLICULAR PHASE IN PATIENTS WITH POLYCYSTIC OVARY SYNDROME: A RANDOMIZED CLINICAL TRIAL

Author(s)

Keywords

ART

GNRH AGONIST

GNRH ANTAGONIST

INFERTILITY

PCOS

Abstract

Background: Since increased LH in the early follicular phase in PCOS patients especially in GNRH ANTAGONIST protocol could be associated with reduced oocyte quality and pregnancy and impared implantation. The current study was conducted to determine ART outcomes in GNRH ANTAGONIST protocol (flexible) and long GNRH AGONIST protocol and compare them with adding GNRH ANTAGONIST in GNRH ANTAGONIST (flexible) protocol during early follicular phase in patients with polycystic ovary syndrome undergoing ICSI.Methods: In this randomized clinical trial, 150 patients with polycystic ovary syndrome undergoing ICSI were enrolled from 2012 to 2014 and randomly assigned to receive either GNRH ANTAGONIST protocol during early and late follicular phase or GNRH ANTAGONIST protocol (flexible) or long GNRH AGONIST protocol. The clinical and laboratory pregnancy in three groups was determined and compared. In this context, the chi-square and Fisher's exact test and ANOVA were used for data analysis.Statistical significance was defined as p<0.05.Results: There was no statistically significant difference with respect to chemical pregnancy and clinical pregnancy between the three groups. Also, other indices such as number and quality of oocytes and embryos were alike.Conclusion: Totally, according to our results, GNRH ANTAGONIST protocol during early and late follicular phase and GNRH ANTAGONIST protocol (flexible) and long GNRH AGONIST protocol in patients with polycystic ovary syndrome undergoing ICSI are similarly effective and use of each one based on patients’ condition and physicians’ opinion could be considered.

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APA: Copy

MOKHTAR, SARA, SADEGHI, MOHAMMAD REZA, AKHONDI, MOHAMMAD MEHDI, ZAFARDOUST, SIMIN, BADENUSH, BITA, FATEMI, FARNAZ, NAZARI, FATTANE, KAMALI, KOOROSH, & MOHAMMADZADEH, AFSANEH. (2015). ART OUTCOMES IN GNRH ANTAGONIST PROTOCOL (FLEXIBLE) AND LONG GNRH AGONIST PROTOCOL DURING EARLY FOLLICULAR PHASE IN PATIENTS WITH POLYCYSTIC OVARY SYNDROME: A RANDOMIZED CLINICAL TRIAL. JOURNAL OF REPRODUCTION AND INFERTILITY, 16(3), 148-154. SID. https://sid.ir/paper/648442/en

Vancouver: Copy

MOKHTAR SARA, SADEGHI MOHAMMAD REZA, AKHONDI MOHAMMAD MEHDI, ZAFARDOUST SIMIN, BADENUSH BITA, FATEMI FARNAZ, NAZARI FATTANE, KAMALI KOOROSH, MOHAMMADZADEH AFSANEH. ART OUTCOMES IN GNRH ANTAGONIST PROTOCOL (FLEXIBLE) AND LONG GNRH AGONIST PROTOCOL DURING EARLY FOLLICULAR PHASE IN PATIENTS WITH POLYCYSTIC OVARY SYNDROME: A RANDOMIZED CLINICAL TRIAL. JOURNAL OF REPRODUCTION AND INFERTILITY[Internet]. 2015;16(3):148-154. Available from: https://sid.ir/paper/648442/en

IEEE: Copy

SARA MOKHTAR, MOHAMMAD REZA SADEGHI, MOHAMMAD MEHDI AKHONDI, SIMIN ZAFARDOUST, BITA BADENUSH, FARNAZ FATEMI, FATTANE NAZARI, KOOROSH KAMALI, and AFSANEH MOHAMMADZADEH, “ART OUTCOMES IN GNRH ANTAGONIST PROTOCOL (FLEXIBLE) AND LONG GNRH AGONIST PROTOCOL DURING EARLY FOLLICULAR PHASE IN PATIENTS WITH POLYCYSTIC OVARY SYNDROME: A RANDOMIZED CLINICAL TRIAL,” JOURNAL OF REPRODUCTION AND INFERTILITY, vol. 16, no. 3, pp. 148–154, 2015, [Online]. Available: https://sid.ir/paper/648442/en

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