ASSOCIATION OF PREGNANCY-ASSOCIATED PLASMA PROTEIN A (PAPP-A) AND GESTATIONAL DIABETES

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RAMEZANI SOMAYEH; AHMADI MAHBOUBEH; SAQHAFI HAMID; ALIPOOR MAHMOOD

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Journal: Iranian Journal of Obstetrics, Gynecology and Infertility Year:2017 | Volume:20 | Issue:1 Page(s): 61-69

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Title

ASSOCIATION OF PREGNANCY-ASSOCIATED PLASMA PROTEIN A (PAPP-A) AND GESTATIONAL DIABETES

Author(s)

RAMEZANI SOMAYEH | AHMADI MAHBOUBEH | SAQHAFI HAMID | ALIPOOR MAHMOOD | Issue Writer Certificate

Keywords

GESTATIONAL DIABETESQ2

PREGNANCY-ASSOCIATED PLASMA PROTEIN AQ1

PREGNANCYQ1

Abstract

Introduction: GESTATIONAL DIABETES mellitus is the most common medical complication during PREGNANCY that negatively affects the health of mother and fetus and neonate. GESTATIONAL DIABETES mellitus occurs in 3-5% of pregnancies. Early detection of GESTATIONAL DIABETES can prevent of these complications. This study was performed with aim to determine the association between PREGNANCY ASSOCIATED PLASMA PROTEIN A/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank"> PREGNANCY-ASSOCIATED PLASMA PROTEIN A (PAPP-A) and GESTATIONAL DIABETES to detect a risk factor for predicting GESTATIONAL DIABETES.Methods: This prospective analytical study was performed on 250 pregnant women referring to six healthcare centers of Qazvin from February to October 2016. PAPP-A was measured at 11-14 gestational weeks, then 75 gr glucose tolerance test was performed on the samples at 24-27 gestational weeks. The association between GESTATIONAL DIABETES and PAPP-A was studied. Data were analyzed by SPSS software (version 21) and Chi-square, t-test, Mann-Whitney, relative risk, and logistic regression. P<0.05 was considered significant.Results: Twenty-four subjects (30.8%) of patients with decreased PAPPA and 15 (8.7%) of patients with normal PAPP-A were diagnosed with GESTATIONAL DIABETES. Chi-square test showed significant difference between two groups based in terms of GESTATIONAL DIABETES (P<0.001). The risk of GESTATIONAL DIABETES in the patients with decreased PAPP-A was 3.90 times more than control group (CI=1.87-8.14, P<0.001).Conclusion: Low level of PAPP-A at gestation weeks of 11-14 can be a possible risk factor for the incidence of GESTATIONAL DIABETES. Therefore, it can be used as an early detection test for preventing the fetal and maternal adverse effects.

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APA: Copy

RAMEZANI, SOMAYEH, AHMADI, MAHBOUBEH, SAQHAFI, HAMID, & ALIPOOR, MAHMOOD. (2017). ASSOCIATION OF PREGNANCY-ASSOCIATED PLASMA PROTEIN A (PAPP-A) AND GESTATIONAL DIABETES. IRANIAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND INFERTILITY, 20(1 ), 61-69. SID. https://sid.ir/paper/65072/en

Vancouver: Copy

RAMEZANI SOMAYEH, AHMADI MAHBOUBEH, SAQHAFI HAMID, ALIPOOR MAHMOOD. ASSOCIATION OF PREGNANCY-ASSOCIATED PLASMA PROTEIN A (PAPP-A) AND GESTATIONAL DIABETES. IRANIAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND INFERTILITY[Internet]. 2017;20(1 ):61-69. Available from: https://sid.ir/paper/65072/en

IEEE: Copy

SOMAYEH RAMEZANI, MAHBOUBEH AHMADI, HAMID SAQHAFI, and MAHMOOD ALIPOOR, “ASSOCIATION OF PREGNANCY-ASSOCIATED PLASMA PROTEIN A (PAPP-A) AND GESTATIONAL DIABETES,” IRANIAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND INFERTILITY, vol. 20, no. 1 , pp. 61–69, 2017, [Online]. Available: https://sid.ir/paper/65072/en

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