Serum level of PAPPA-A (pregnancy associated plasma protein-A) at first trimesterand its relation with adverse pregnancy outcome

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Yosefi Khangah Bita; TOOBA KHATEREH; SHARGHI AFSHAN

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Journal: MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES Year:2019 | Volume:41 | Issue:4 Page(s): 110-118

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Title

Serum level of PAPPA-A (pregnancy associated plasma protein-A) at first trimesterand its relation with adverse pregnancy outcome

Author(s)

Yosefi Khangah Bita | TOOBA KHATEREH | SHARGHI AFSHAN | Issue Writer Certificate

Keywords

PAPP-A serum levelQ1

First trimester of pregnancyQ2

Consequences of pregnancyQ1

Abstract

Background: PAPP-A is a preterm marker for undesirable pregnancy diagnosis. The relationship between PAPP-A serum levels and maternal health, especially gestational diabetes, which is the most common outcome of pregnancy, is a major issue that needs to be studied. The aim of this study were to evaluate the serum level of PAPP-A and pregnancy outcomes. Methods: in this study all pregnant women who referred to the pregnancy care clinics during their first 3 months, serum levels of PAPP-A were evaluated. As their PAPP-A serum level were less than 0. 4 Mom, they were considered as risk-positive and pregnant women with a serum PAPP-A level of more than 0. 4 MM as a control group. In the subjects, maternal age, serum PAPP-A level, type of delivery, gestational age, intrauterine growth restriction, preeclampsia, spontaneous abortion, and gestational diabetes were evaluated. Results: The mean age of pregnant women were 26. 85 ± 4. 74 years. There were a significant reverse correlation between serum concentration of first trimesters PAPP-A and preeclampsia (p=0. 003), pregnancy Diabetes (p=0. 003), restriction of intrauterine growth (p=0. 005) and spontaneous abortion (p=0. 04), but there were not significant corrections between serum level of PAPP-A with early birth (p=0. 102) and gestation type (p=0. 583). Conclusion: A reduced amount of first trimester PAPP-A would used as a probable risk factor in complications of pregnancy or embryo including preeclampsia, Gestational Diabetes, restriction of intrauterine growth and spontaneous abortion.

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APA: Copy

Yosefi Khangah, Bita, TOOBA, KHATEREH, & SHARGHI, AFSHAN. (2019). Serum level of PAPPA-A (pregnancy associated plasma protein-A) at first trimesterand its relation with adverse pregnancy outcome. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 41(4 ), 110-118. SID. https://sid.ir/paper/396400/en

Vancouver: Copy

Yosefi Khangah Bita, TOOBA KHATEREH, SHARGHI AFSHAN. Serum level of PAPPA-A (pregnancy associated plasma protein-A) at first trimesterand its relation with adverse pregnancy outcome. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;41(4 ):110-118. Available from: https://sid.ir/paper/396400/en

IEEE: Copy

Bita Yosefi Khangah, KHATEREH TOOBA, and AFSHAN SHARGHI, “Serum level of PAPPA-A (pregnancy associated plasma protein-A) at first trimesterand its relation with adverse pregnancy outcome,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 41, no. 4 , pp. 110–118, 2019, [Online]. Available: https://sid.ir/paper/396400/en

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