ANALYSIS OF SEX CHROMOSOMES DISORDERS IN PREIMPLANTATION GENETIC DIAGNOSIS

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SAHEB KASHAF H.; ALE YASIN ASHRAF; KEY NEZHAD P.; SAHEBKASHAF S.; JAHAN SHAD F.; MOHAMMADI ZIAZI L.

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Journal: Iranian Journal of Obstetrics, Gynecology and Infertility Year:2008 | Volume:10 | Issue:2 Page(s): 127-132

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Title

ANALYSIS OF SEX CHROMOSOMES DISORDERS IN PREIMPLANTATION GENETIC DIAGNOSIS

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Keywords

PREIMPLANTATION GENETIC DIAGNOSISQ3

SEX CHROMOSOMESQ3

INVITRO FERTILIZATIONQ2

EMBRYO BIOPSYQ3

FISHQ3

Abstract

Introduction: PREIMPLANTATION GENETIC DIAGNOSIS (PGD) is an advanced diagnostic tool in the assisted reproductive technologies (ARTs) to avoid inheritance of genetic disease by transferring unaffected embryos. The presence of numerical sex chromosome abnormalities was studied using fluorescence in situ hybridization (FISH) with two sex chromosome specific probes for X and Y chromosomes. Material and Methods: In this experimental study, PGD has been performed for 10 couples, who were carriers of inherited X linked disorders. Conventional hormone therapy, intracytoplasmic sperm injection, blastomer, biopsy and fluorescent in situ hybridization were carried out for all candidates. Results: Data was analyzed by descriptive statistics.In FISH analysis 93% of cells provides clear signals for X and Y chromosomes from that 29 (XX), 18 (XY), 4 (XXY), 1 (XO) were diagnosed. Transferring of embryos into uterus was performed in 10 cycles resulting into two pregnancies and one born baby. The implantation rate of embryos was 20% and the take home baby rate was 10% following ten PGD experiments.Conclusion: Chromosomal disorders more frequently in embryos with dismorphology especially in the embryos from older women.

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APA: Copy

SAHEB KASHAF, H., ALE YASIN, ASHRAF, KEY NEZHAD, P., SAHEBKASHAF, S., JAHAN SHAD, F., & MOHAMMADI ZIAZI, L.. (2008). ANALYSIS OF SEX CHROMOSOMES DISORDERS IN PREIMPLANTATION GENETIC DIAGNOSIS. IRANIAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND INFERTILITY, 10(2), 127-132. SID. https://sid.ir/paper/65225/en

Vancouver: Copy

SAHEB KASHAF H., ALE YASIN ASHRAF, KEY NEZHAD P., SAHEBKASHAF S., JAHAN SHAD F., MOHAMMADI ZIAZI L.. ANALYSIS OF SEX CHROMOSOMES DISORDERS IN PREIMPLANTATION GENETIC DIAGNOSIS. IRANIAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND INFERTILITY[Internet]. 2008;10(2):127-132. Available from: https://sid.ir/paper/65225/en

IEEE: Copy

H. SAHEB KASHAF, ASHRAF ALE YASIN, P. KEY NEZHAD, S. SAHEBKASHAF, F. JAHAN SHAD, and L. MOHAMMADI ZIAZI, “ANALYSIS OF SEX CHROMOSOMES DISORDERS IN PREIMPLANTATION GENETIC DIAGNOSIS,” IRANIAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND INFERTILITY, vol. 10, no. 2, pp. 127–132, 2008, [Online]. Available: https://sid.ir/paper/65225/en

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