ON THE PROTECTION BY THE COMBINATION OF CEO2 NANOPARTICLES AND SODIUM SELENITE ON HUMAN LYMPHOCYTES AGAINST CHLORPYRIFOS-INDUCED APOPTOSIS IN VITRO

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PEDRAM SAHAR; MOHAMMADIRAD AZADEH; REZVANFAR MOHAMMAD AMIN; NAVAEI NIGJEH MONA; BAEERI MARYAM; ABDOLLAHI MOHAMMAD

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Journal: Cell Journal (Yakhteh) Year:2015 | Volume:17 | Issue:2 Page(s): 361-371

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Title

ON THE PROTECTION BY THE COMBINATION OF CEO2 NANOPARTICLES AND SODIUM SELENITE ON HUMAN LYMPHOCYTES AGAINST CHLORPYRIFOS-INDUCED APOPTOSIS IN VITRO

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Keywords

ORGANOPHOSPHORUS

CHLORPYRIFOS

LYMPHOCYTES

CERIUM OXIDE NANOPARTICLES

SODIUM SELENITE

Abstract

Objective: CHLORPYRIFOS (CP) as an ORGANOPHOSPHORUS pesticide is thought to induce oxidative stress in human cells via producing reactive oxygen species (ROS) that leads to the presence of pathologic conditions due to apoptosis along with acetylcholinesterase (AChE) inhibition.This study aimed to evaluate the apoptotic effects of CP and to assess the protective potential of CeO2 nanoparticle (CNP) and SODIUM SELENITE (SSe) by measuring cascades of apoptosis, oxidative stress, inflammation, and AChE inhibition in human isolated LYMPHOCYTES.Materials and Methods: In the present experimental study, we examined the anti-oxidative and AChE activating potential of CNP and SSe in CP-treated human LYMPHOCYTES. Therefore, the LYMPHOCYTES were isolated and exposed to CP, CP+CNP, CP+SSe, and CP+CNP+SSe after a three-day incubation. Then tumor necrosis factor-alpha (TNF-a) release, myeloperoxidase (MPO) activity, thiobarbituric acid-reactive substances (TBARS) levels as inflammatory/oxidative stress indices along with AChE activity were assessed. In addition, the apoptotic process was measured by flow cytometry.Results: Results showed a significant reduction in the mortality rate, TNF-a, MPO activity, TBARS, and apoptosis rate in cells treated with CNP, SSe and their combination. Interestingly, both CNP and SSe were able to activate AChE which is inhibited by CP. The results supported the synergistic effect of CNP/SSe combination in the prevention of apoptosis along with oxidative stress and inflammatory cascade.Conclusion: CP induces apoptosis in isolated human LYMPHOCYTES via oxidative stress and inflammatory mediators. CP firstly produces ROS, which leads to membrane phospholipid damage. The beneficial effects of CNP and SSe in reduction of CP-induced apoptosis and restoring AChE inhibition relate to their anti-oxidative potentials.

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APA: Copy

PEDRAM, SAHAR, MOHAMMADIRAD, AZADEH, REZVANFAR, MOHAMMAD AMIN, NAVAEI NIGJEH, MONA, BAEERI, MARYAM, & ABDOLLAHI, MOHAMMAD. (2015). ON THE PROTECTION BY THE COMBINATION OF CEO₂ NANOPARTICLES AND SODIUM SELENITE ON HUMAN LYMPHOCYTES AGAINST CHLORPYRIFOS-INDUCED APOPTOSIS IN VITRO. CELL JOURNAL (YAKHTEH), 17(2), 361-371. SID. https://sid.ir/paper/652722/en

Vancouver: Copy

PEDRAM SAHAR, MOHAMMADIRAD AZADEH, REZVANFAR MOHAMMAD AMIN, NAVAEI NIGJEH MONA, BAEERI MARYAM, ABDOLLAHI MOHAMMAD. ON THE PROTECTION BY THE COMBINATION OF CEO₂ NANOPARTICLES AND SODIUM SELENITE ON HUMAN LYMPHOCYTES AGAINST CHLORPYRIFOS-INDUCED APOPTOSIS IN VITRO. CELL JOURNAL (YAKHTEH)[Internet]. 2015;17(2):361-371. Available from: https://sid.ir/paper/652722/en

IEEE: Copy

SAHAR PEDRAM, AZADEH MOHAMMADIRAD, MOHAMMAD AMIN REZVANFAR, MONA NAVAEI NIGJEH, MARYAM BAEERI, and MOHAMMAD ABDOLLAHI, “ON THE PROTECTION BY THE COMBINATION OF CEO₂ NANOPARTICLES AND SODIUM SELENITE ON HUMAN LYMPHOCYTES AGAINST CHLORPYRIFOS-INDUCED APOPTOSIS IN VITRO,” CELL JOURNAL (YAKHTEH), vol. 17, no. 2, pp. 361–371, 2015, [Online]. Available: https://sid.ir/paper/652722/en

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