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Information Journal Paper

Title

SUPPRESSIVE EFFECTS OF RESVERATROL TREATMENT ON THE INTRINSIC EVOKED EXCITABILITY OF CA1 PYRAMIDAL NEURONS

Pages

  532-539

Abstract

 Objective: RESVERATROL, a phytoalexin, has a wide range of desirable biological actions.Despite a growing body of evidence indicating that RESVERATROL induces changes in neuronal function, little effort, if any, has been made to investigate the cellular effect of RESVERATROL treatment on intrinsic neuronal properties.Materials and Methods: This experimental study was performed to examine the acute effects of RESVERATROL (100 μM) on the intrinsic evoked responses of rat Cornu Ammonis (CA1) pyramidal NEURONS in brain slices, using WHOLE CELL PATCH CLAMP recording under current clamp conditions.Results: Findings showed that RESVERATROL treatment caused dramatic changes in evoked responses of pyramidal NEURONS. Its treatment induced a significant (P<0.05) increase in the after hyperpolarization amplitude of the first evoked ACTION POTENTIAL.RESVERATROL-treated cells displayed a significantly broader ACTION POTENTIAL (AP) when compared with either control or vehicle-treated groups. In addition, the mean instantaneousfiring frequency between the first two ACTION POTENTIALs was significantly lower in RESVERATROL-treated NEURONS. It also caused a significant reduction in the time to maximum decay of AP. The rheobase current and the utilization time were both significantly greater following RESVERATROL treatment. NEURONS exhibited a significantly depolarized voltage threshold when exposed to RESVERATROL.Conclusion: Results provide direct electrophysiological evidence for the inhibitory effects of RESVERATROL on pyramidal NEURONS, at least in part, by reducing the evoked neural activity.

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    Cite

    APA: Copy

    MEFTAHI, GHOLAMHOSSEIN, GHOTBEDIN, ZOHREH, ESLAMIZADE, MOHAMMAD JAVAD, HOSSEINMARDI, NARGES, & JANAHMADI, MAHYAR. (2015). SUPPRESSIVE EFFECTS OF RESVERATROL TREATMENT ON THE INTRINSIC EVOKED EXCITABILITY OF CA1 PYRAMIDAL NEURONS. CELL JOURNAL (YAKHTEH), 17(3 (67)), 532-539. SID. https://sid.ir/paper/658570/en

    Vancouver: Copy

    MEFTAHI GHOLAMHOSSEIN, GHOTBEDIN ZOHREH, ESLAMIZADE MOHAMMAD JAVAD, HOSSEINMARDI NARGES, JANAHMADI MAHYAR. SUPPRESSIVE EFFECTS OF RESVERATROL TREATMENT ON THE INTRINSIC EVOKED EXCITABILITY OF CA1 PYRAMIDAL NEURONS. CELL JOURNAL (YAKHTEH)[Internet]. 2015;17(3 (67)):532-539. Available from: https://sid.ir/paper/658570/en

    IEEE: Copy

    GHOLAMHOSSEIN MEFTAHI, ZOHREH GHOTBEDIN, MOHAMMAD JAVAD ESLAMIZADE, NARGES HOSSEINMARDI, and MAHYAR JANAHMADI, “SUPPRESSIVE EFFECTS OF RESVERATROL TREATMENT ON THE INTRINSIC EVOKED EXCITABILITY OF CA1 PYRAMIDAL NEURONS,” CELL JOURNAL (YAKHTEH), vol. 17, no. 3 (67), pp. 532–539, 2015, [Online]. Available: https://sid.ir/paper/658570/en

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