SHORT COMMUNICATION: RESTORATION OF CPG METHYLATION IN THE EGF PROMOTER REGION DURING RAT LIVER REGENERATION

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LI DEMING; LI ZIWEI; GUO XUEQIANG; XU CUNSHUAN

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Journal Paper

Paper Information

Journal: Cell Journal (Yakhteh) Year:2015 | Volume:17 | Issue:3 (67) Page(s): 576-581

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Title

SHORT COMMUNICATION: RESTORATION OF CPG METHYLATION IN THE EGF PROMOTER REGION DURING RAT LIVER REGENERATION

Author(s)

LI DEMING | LI ZIWEI | GUO XUEQIANG | XU CUNSHUAN | Issue Writer Certificate

Keywords

EPIDERMAL GROWTH FACTOR

METHYLATION

LIVER REGENERATION

Abstract

EPIDERMAL GROWTH FACTOR (EGF) is an important factor for healing after tissue damage in diverse experimental models. It plays an important role in LIVER REGENERATION (LR). The objective of this experiment is to investigate the METHYLATION variation of 10 CpG sites in the Egf promoter region and their relevance to Egf expression during rat LIVER REGENERATION.As a follow up of our previous study, rat liver tissue was collected after rat 2/3 partial hepatectomy (PH) during the re-organization phase (from days 14 to days 28). Liver DNA was extracted and modified by sodium bisulfate. The METHYLATION status of 10 CpG sites in Egfpromoter region was determined using bisulfite sequencing polymerase chain reaction (PCR), as BSP method. The results showed that 3 (sites 3, 4 and 9) out of 10 CpG sites have strikingly METHYLATION changes during the re-organization phase compared to the regeneration phase (from 2 hours to 168 hours, P=0.002, 0.048 and 0.018, respectively).Our results showed that METHYLATION modification of CpGs in theEgf promoter region could be restored to the status before PH operation and changes of METHYLATION didn’t affectEgf mRNA expression during the re-organization phase.

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APA: Copy

LI, DEMING, LI, ZIWEI, GUO, XUEQIANG, & XU, CUNSHUAN. (2015). SHORT COMMUNICATION: RESTORATION OF CPG METHYLATION IN THE EGF PROMOTER REGION DURING RAT LIVER REGENERATION. CELL JOURNAL (YAKHTEH), 17(3 (67)), 576-581. SID. https://sid.ir/paper/659885/en

Vancouver: Copy

LI DEMING, LI ZIWEI, GUO XUEQIANG, XU CUNSHUAN. SHORT COMMUNICATION: RESTORATION OF CPG METHYLATION IN THE EGF PROMOTER REGION DURING RAT LIVER REGENERATION. CELL JOURNAL (YAKHTEH)[Internet]. 2015;17(3 (67)):576-581. Available from: https://sid.ir/paper/659885/en

IEEE: Copy

DEMING LI, ZIWEI LI, XUEQIANG GUO, and CUNSHUAN XU, “SHORT COMMUNICATION: RESTORATION OF CPG METHYLATION IN THE EGF PROMOTER REGION DURING RAT LIVER REGENERATION,” CELL JOURNAL (YAKHTEH), vol. 17, no. 3 (67), pp. 576–581, 2015, [Online]. Available: https://sid.ir/paper/659885/en

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