CLINICAL TRIAL OF VIGABATRIN AS ADJUNCTIVE THERAPY IN CHILDREN WITH REFRACTORY EPILEPSY

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TAGHDIRI MOHAMMAD MAHDI; ASHRAFI MAHMOUD REZA; BAKHSHANDEH BALI MOHAMMAD KAZEM; TAHERI OTAGHSARA SEYEDEH MOHADESEH; NASEHI MOHAMMAD MAHDI; GHOFRANI MOHAMMAD

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Journal: Iranian Journal of Pediatrics Year:2013 | Volume:23 | Issue:6 Page(s): 653-658

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Title

CLINICAL TRIAL OF VIGABATRIN AS ADJUNCTIVE THERAPY IN CHILDREN WITH REFRACTORY EPILEPSY

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Keywords

INTRACTABLE EPILEPSY

ANTIEPILEPTIC DRUGS

VIGABATRIN

ADD-ON THERAPY

Abstract

Objective: Approximately one-third of all children with epilepsy do not achieve complete seizure improvement. This study evaluated the efficacy of VIGABATRIN in children with INTRACTABLE EPILEPSY.Methods: From November 2011 to October 2012, 73 children with refractory epilepsy (failure of seizure control with the use of two or more anticonvulsant drugs) who were referred to the Children's Medical Center and Mofid Children's Hospital were included in the study. The patients were treated with VIGABATRIN in addition to their previous medication, and followed-up after three to four weeks to determine the daily frequency, severity, and duration of seizures in addition to any reported side effects.Findings: Of the 67 children, 41 (61.2%) were males and 26 (38.8%) females, their age ranging from three months to 13 years with an average of 3.1 [standard deviation (SD), 2.6] years. The mean daily frequency of seizures at baseline was 6.61 (SD, 5.9) seizures per day. VIGABATRIN reduced the seizure frequency ≤2.9 (SD, 5.2) (56% decline) and 3.0 (SD, 5.3) (54.5% decline) per day after three and six months of treatment, respectively. A significant difference was observed between seizure frequencies at three (P<0.001) and six months (P<0.001) after VIGABATRIN initiation compared with the baseline. Somnolence [3 (4.5%)], horse laugh [1 (1.5%)], urinary stones [1 (1.5%)], increased appetite [1 (1.5%)], and abnormal electroretinographic pattern [3 (4.5%)] were the most common side effects in our patients.Conclusion: This study confirms the short-term efficacy and safety of VIGABATRIN in children with refractory epilepsies.

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APA: Copy

TAGHDIRI, MOHAMMAD MAHDI, ASHRAFI, MAHMOUD REZA, BAKHSHANDEH BALI, MOHAMMAD KAZEM, TAHERI OTAGHSARA, SEYEDEH MOHADESEH, NASEHI, MOHAMMAD MAHDI, & GHOFRANI, MOHAMMAD. (2013). CLINICAL TRIAL OF VIGABATRIN AS ADJUNCTIVE THERAPY IN CHILDREN WITH REFRACTORY EPILEPSY. IRANIAN JOURNAL OF PEDIATRICS, 23(6), 653-658. SID. https://sid.ir/paper/660216/en

Vancouver: Copy

TAGHDIRI MOHAMMAD MAHDI, ASHRAFI MAHMOUD REZA, BAKHSHANDEH BALI MOHAMMAD KAZEM, TAHERI OTAGHSARA SEYEDEH MOHADESEH, NASEHI MOHAMMAD MAHDI, GHOFRANI MOHAMMAD. CLINICAL TRIAL OF VIGABATRIN AS ADJUNCTIVE THERAPY IN CHILDREN WITH REFRACTORY EPILEPSY. IRANIAN JOURNAL OF PEDIATRICS[Internet]. 2013;23(6):653-658. Available from: https://sid.ir/paper/660216/en

IEEE: Copy

MOHAMMAD MAHDI TAGHDIRI, MAHMOUD REZA ASHRAFI, MOHAMMAD KAZEM BAKHSHANDEH BALI, SEYEDEH MOHADESEH TAHERI OTAGHSARA, MOHAMMAD MAHDI NASEHI, and MOHAMMAD GHOFRANI, “CLINICAL TRIAL OF VIGABATRIN AS ADJUNCTIVE THERAPY IN CHILDREN WITH REFRACTORY EPILEPSY,” IRANIAN JOURNAL OF PEDIATRICS, vol. 23, no. 6, pp. 653–658, 2013, [Online]. Available: https://sid.ir/paper/660216/en

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