UPREGULATION OF RHOXF2 AND ODF4 EXPRESSION IN BREAST CANCER TISSUES

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KAZEMI OULA GOLNESA; GHAFOURI FARD SOUDEH; BEIGOM MOBASHERI MARYAM; GERANPAYEH LOBAT; MODARRESSI MOHAMMAD HOSSEIN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Cell Journal (Yakhteh) Year:2015 | Volume:17 | Issue:3 (67) Page(s): 471-477

Download Full-Text

View:

424

Download:

409

Cites:

Information Journal Paper

Title

UPREGULATION OF RHOXF2 AND ODF4 EXPRESSION IN BREAST CANCER TISSUES

Author(s)

Keywords

BREAST CANCER

CANCER-TESTIS ANTIGEN

ODF4

RHOXF2

Abstract

Objective: During the past decade, the importance of biomarker discovery has been highlighted in many aspects of cancer research. Biomarkers may have a role in early detection of cancer, prognosis and survival evaluation as well as drug response. CANCER-TESTIS ANTIGENs (CTAs) have gained attention as cancer biomarkers because of their expression in a wide variety of tumors and restricted expression in testis. The aim of this study was to find putative biomarkers for BREAST CANCER.Materials and Methods: In this applied-descriptive study, the expression of 4 CTAs, namely acrosin binding protein (ACRBP), outer dense fiber 4 (ODF4), Rhox homeobox family member 2 (RHOXF2) and spermatogenesis associated 19 (SPATA19) were analyzed at the transcript level in two BREAST CANCER lines (MCF-7 and MDA-MB-231), 40 invasive ductal carcinoma samples and their adjacent normal tissues as well as 10 fibroadenoma samples by means of quantitative real-time reverse transcription polymerase chain reaction (RT-PCR).Results: All four genes were expressed in both cell lines. Expression of ODF4 and RHOXF2 was detected in 62.5% and 60% of BREAST CANCER tissues but in 22.5 and 17.5% of normal tissues examined respectively. The expression of bothRHOXF2 and ODF4 was upregulated in cancerous tissues compared with their normal adjacent tissues by 3.31- and 2.96-fold respectively. The expression of both genes was correlated with HER2/neu overexpression.RHOXF2 expression but not ODF4 was correlated with higher stages of tumors. However, no significant association was seen between expression patterns and estrogen and progesterone receptors status.Conclusion: ODF4 and RHOXF2 are proposed as putative BREAST CANCER biomarkers at the transcript level. However, their expression at protein level should be evaluated in future studies.

Cites

THE ROLE OF LONG NON-CODING RNAS IN BREAST CANCER

References

Cite

APA: Copy

KAZEMI OULA, GOLNESA, GHAFOURI FARD, SOUDEH, BEIGOM MOBASHERI, MARYAM, GERANPAYEH, LOBAT, & MODARRESSI, MOHAMMAD HOSSEIN. (2015). UPREGULATION OF RHOXF2 AND ODF4 EXPRESSION IN BREAST CANCER TISSUES. CELL JOURNAL (YAKHTEH), 17(3 (67)), 471-477. SID. https://sid.ir/paper/660385/en

Vancouver: Copy

KAZEMI OULA GOLNESA, GHAFOURI FARD SOUDEH, BEIGOM MOBASHERI MARYAM, GERANPAYEH LOBAT, MODARRESSI MOHAMMAD HOSSEIN. UPREGULATION OF RHOXF2 AND ODF4 EXPRESSION IN BREAST CANCER TISSUES. CELL JOURNAL (YAKHTEH)[Internet]. 2015;17(3 (67)):471-477. Available from: https://sid.ir/paper/660385/en

IEEE: Copy

GOLNESA KAZEMI OULA, SOUDEH GHAFOURI FARD, MARYAM BEIGOM MOBASHERI, LOBAT GERANPAYEH, and MOHAMMAD HOSSEIN MODARRESSI, “UPREGULATION OF RHOXF2 AND ODF4 EXPRESSION IN BREAST CANCER TISSUES,” CELL JOURNAL (YAKHTEH), vol. 17, no. 3 (67), pp. 471–477, 2015, [Online]. Available: https://sid.ir/paper/660385/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops