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Information Journal Paper

Title

EFFECTS OF ALOE VERA, CAMELLIA SINENSIS, HIBISCUS SABDARIFFA AND SOPHORA ALOPECUROIDES IN RAT MODEL OF INDOMETHACIN-INDUCED GASTRIC ULCER

Pages

  58-65

Abstract

 Background: Evidences show that Aloe vera (A. vera), Camellia sinensis, Hibiscus sabdariffa and Sophora alopecuroides may prevent gastric ulcer induced by NON-STEROIDAL ANTI-INFLAMMATORY DRUGs (NSAIDs).Objective: To examine the protective potential of these plants against indomethacin-induced gastric ulcer in the RAT.Methods: Saline, A. vera leaf gel powder and 70% alcoholic extracts of the other 3 plants (100, 400, 800 mg/kg) and omeprazole (30 mg/kg) were gavaged to the groups of 10 animals for 4 consecutive days. Gastric ulcers were induced by the onetime gavage of indomethacin (30 mg/kg). On the fifth day, each group was pretreated with physiological saline as control, extract (100, 400 or 800 mg/kg) or omeprazole (30 mg/kg) 30 min before the indomethacin administration. The animals were killed 6 h after the indomethacin administration. The stomachs were removed, opened along the greater curvature and washed in physiological saline. A person unaware of the type of treatment received by the animals examined the stomachs under a 3-fold magnifier. The areas and lengths of hemorrhagic lesions induced by indomethacin were measured using a dial caliper and the sum of measurements for each animal was referred to as the ulcer index.Results: All doses of the A. vera leaf gel powder and extracts reduced the ulcer index significantly compared to the control group (p<0.05).Conclusion: These plants have protective effect against NSAID-induced gastric ulcer in the RAT. The A. vera leaf gel seems noticeably more effective than the other 3 plants in this respect.

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    APA: Copy

    FALLAH HUSEINI, H., KIANBAKHT, S., & RADJABIAN, T.. (2015). EFFECTS OF ALOE VERA, CAMELLIA SINENSIS, HIBISCUS SABDARIFFA AND SOPHORA ALOPECUROIDES IN RAT MODEL OF INDOMETHACIN-INDUCED GASTRIC ULCER. JOURNAL OF MEDICINAL PLANTS, 14(55), 58-65. SID. https://sid.ir/paper/660995/en

    Vancouver: Copy

    FALLAH HUSEINI H., KIANBAKHT S., RADJABIAN T.. EFFECTS OF ALOE VERA, CAMELLIA SINENSIS, HIBISCUS SABDARIFFA AND SOPHORA ALOPECUROIDES IN RAT MODEL OF INDOMETHACIN-INDUCED GASTRIC ULCER. JOURNAL OF MEDICINAL PLANTS[Internet]. 2015;14(55):58-65. Available from: https://sid.ir/paper/660995/en

    IEEE: Copy

    H. FALLAH HUSEINI, S. KIANBAKHT, and T. RADJABIAN, “EFFECTS OF ALOE VERA, CAMELLIA SINENSIS, HIBISCUS SABDARIFFA AND SOPHORA ALOPECUROIDES IN RAT MODEL OF INDOMETHACIN-INDUCED GASTRIC ULCER,” JOURNAL OF MEDICINAL PLANTS, vol. 14, no. 55, pp. 58–65, 2015, [Online]. Available: https://sid.ir/paper/660995/en

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