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Information Journal Paper

Title

THE EFFECTS OF CO-ADMINISTRATION OF IMMOBILIZATION STRESS AND ALOE VERA ON SERUM CARCINOEMBRYONIC ANTIGEN IN RATS

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  0-0

Abstract

 Background: IMMOBILIZATION has been used extensively and accepted widely for studying stress-induced alterations. To determine the protective effects of ALOE VERA leaf extract, we evaluated the effects of co-administration of IMMOBILIZATION stress and ALOE VERA leaf extract on serum level of CARCINOEMBRYONIC ANTIGEN (CEA) tumor marker in male RATs.Materials and Methods: In this experimental study, 45 male Wistar RATs were randomly divided into 9 groups of 5 RATs in each including: 1) control, 2) normal saline receiving, 3) ALOE VERA extract receiving, 4) acutely immobilized, 5) chronically immobilized, 6) acutely immobilized+Aloe vera extract, 7) chronically immobilized+Aloe vera extract, 8) acutely immobilized+normal saline and 9) chronically immobilized + normal saline. The animals were exposed to chronic or acute IMMOBILIZATION stress for 2 h/day or 8 h/day for a period of 3 weeks or one week, respectively. ALOE VERA extract (300 mg/kg/day) was fed by gavage feeding orally. Blood samples were collected and following serum collection, CEA level was determined by radioimmunoassay method. Data were compared statistically between groups using ANOVA.Results: Serum CEA level was significantly increased in acutely (0.640±0.025 ng/mL) or chronically immobilized (0.647±0.023 ng/mL) RATs compared with control animals group (0.564±0.014 ng/mL) (p<0.001). However, there was no significant difference between serum CEA levels of acutely or chronically immobilized ALOE VERA extract received animals compared with control RATs (0.622±0.027 ng/m and 0.616±0.044 ng/mL, respectively).Conclusion: Our findings indicate that IMMOBILIZATION stress enhances serum CEA level, however, intake of ALOE VERA extract can withstand against.

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    APA: Copy

    AHMADI, RAHIM, & MOLAEI, SEDIGHEH. (2015). THE EFFECTS OF CO-ADMINISTRATION OF IMMOBILIZATION STRESS AND ALOE VERA ON SERUM CARCINOEMBRYONIC ANTIGEN IN RATS. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 17(3), 0-0. SID. https://sid.ir/paper/664596/en

    Vancouver: Copy

    AHMADI RAHIM, MOLAEI SEDIGHEH. THE EFFECTS OF CO-ADMINISTRATION OF IMMOBILIZATION STRESS AND ALOE VERA ON SERUM CARCINOEMBRYONIC ANTIGEN IN RATS. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2015;17(3):0-0. Available from: https://sid.ir/paper/664596/en

    IEEE: Copy

    RAHIM AHMADI, and SEDIGHEH MOLAEI, “THE EFFECTS OF CO-ADMINISTRATION OF IMMOBILIZATION STRESS AND ALOE VERA ON SERUM CARCINOEMBRYONIC ANTIGEN IN RATS,” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 17, no. 3, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/664596/en

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