مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

EFFECTS OF L-ARGININE PRE-TREATMENT IN 1-METHYL-4-PHENYL-1, 2, 3, 6- TETRAHYDROPYRIDINE-INDUCED PARKINSON’S DISEASES IN BALB/C MICE

Pages

  195-203

Abstract

 Background: Parkinson’s disease (PD) is a common neurodegenerative disease resulting from the degeneration of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Increasing evidence demonstrated that mice treated intranasally with 1-METHYL-4-PHENYL-1, 2, 3, 6-tetrahydropyridine (MPTP) suffered impairments in motor functions associated with disruption of DA neurons in SNc conceivably analogous to those observed in PD. Larginine has been proposed as a novel neuroprotective agent that plays protective roles in several models of neuronal cellular damage. This study aimed to evaluate the effects of L-arginine on the numerical density of dark neurons (DNs) in the SNc of Balb/c mice subjected to MPTP administration. Methods: In the present study, we demonstrated that repeated treatment with L-arginine (300 mg/kg, i.p.) during 7 consecutive days attenuated the production of DNs in SNc of adult male Balb/c mice infused with a single intranasal administration of MPTP (1 mg/nostril).Results: Pre-treatment with L-arginine significantly decreased the numerical density of DNs in SNc of mice 21 days after intranasal MPTP administration.Conclusion: This investigation provides new insights in experimental models of PD, indicating that L-arginine represents a potential neuroprotective agent for the prevention of DA neuron degeneration in SNc observed in PD patients.

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    APA: Copy

    HAMI, JAVAD, HOSSEINI, MEHRAN, SHAHI, SEKINEH, LOTFI, NASSIM, TALEBI, ABOLFAZL, & AFSHAR, MOHAMMAD. (2015). EFFECTS OF L-ARGININE PRE-TREATMENT IN 1-METHYL-4-PHENYL-1, 2, 3, 6- TETRAHYDROPYRIDINE-INDUCED PARKINSON’S DISEASES IN BALB/C MICE. CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY), 14(4), 195-203. SID. https://sid.ir/paper/665145/en

    Vancouver: Copy

    HAMI JAVAD, HOSSEINI MEHRAN, SHAHI SEKINEH, LOTFI NASSIM, TALEBI ABOLFAZL, AFSHAR MOHAMMAD. EFFECTS OF L-ARGININE PRE-TREATMENT IN 1-METHYL-4-PHENYL-1, 2, 3, 6- TETRAHYDROPYRIDINE-INDUCED PARKINSON’S DISEASES IN BALB/C MICE. CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY)[Internet]. 2015;14(4):195-203. Available from: https://sid.ir/paper/665145/en

    IEEE: Copy

    JAVAD HAMI, MEHRAN HOSSEINI, SEKINEH SHAHI, NASSIM LOTFI, ABOLFAZL TALEBI, and MOHAMMAD AFSHAR, “EFFECTS OF L-ARGININE PRE-TREATMENT IN 1-METHYL-4-PHENYL-1, 2, 3, 6- TETRAHYDROPYRIDINE-INDUCED PARKINSON’S DISEASES IN BALB/C MICE,” CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY), vol. 14, no. 4, pp. 195–203, 2015, [Online]. Available: https://sid.ir/paper/665145/en

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