ARE OSTEOPONTIN AND KI67 EXPRESSIONS DIFFERENT IN VARIOUS HISTOLOGIC GRADES OF MENINGIOMA? AN IRANIAN EXPERIENCE

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HASHEMI FOROUGH; BABAHEIDARIAN PEGAH; DABIRAN SOHEILA

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Journal: IRANIAN JOURNAL OF PATHOLOGY (IJP) Year:2015 | Volume:10 | Issue:4 Page(s): 253-257

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Title

ARE OSTEOPONTIN AND KI67 EXPRESSIONS DIFFERENT IN VARIOUS HISTOLOGIC GRADES OF MENINGIOMA? AN IRANIAN EXPERIENCE

Author(s)

HASHEMI FOROUGH | BABAHEIDARIAN PEGAH | DABIRAN SOHEILA | Issue Writer Certificate

Keywords

MENINGIOMA

KI67 ANTIGEN

OSTEOPONTIN

Abstract

Background: MENINGIOMA is among the most common slow growing central nervous neoplasms, which recurs locally despite the benign histologic features. The aim of this study was to evaluate OSTEOPONTIN and ki67 expressions in different histologic grades of MENINGIOMA in a group of Iranian people.Methods: In this cross-sectional study, first, the paraffin blocks with the definite pathological diagnosis of MENINGIOMA in 70 patients were cut by microtome, in 4-5 micron sizes and stained for immunohistochemical markers of OSTEOPONTIN and ki67. Then, all samples were evaluated for positive immunoreactivity and contributing factors. Results: Among 70 pateints studied, the mean for the Ki67 level was 8.6±12.3 and the mean for the OSTEOPONTINm IHC score was 45.2±77.9. There was a high correlation between markers, tumor recurrence and grade (P<0.001). In addition, there was a significant direct correlation between ki67 and OSTEOPONTIN levels (P<0.001, r=0.760). In other words, as OPN and ki67 expressions increased, the chance of tumor recurrence increased.Conclusion: ki67 and OSTEOPONTIN expressions in patients with MENINGIOMA can be used as good prognostic markers for tumor recurrence and for distinguishing the grade of MENINGIOMAs.

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APA: Copy

HASHEMI, FOROUGH, BABAHEIDARIAN, PEGAH, & DABIRAN, SOHEILA. (2015). ARE OSTEOPONTIN AND KI67 EXPRESSIONS DIFFERENT IN VARIOUS HISTOLOGIC GRADES OF MENINGIOMA? AN IRANIAN EXPERIENCE. IRANIAN JOURNAL OF PATHOLOGY (IJP), 10(4), 253-257. SID. https://sid.ir/paper/665163/en

Vancouver: Copy

HASHEMI FOROUGH, BABAHEIDARIAN PEGAH, DABIRAN SOHEILA. ARE OSTEOPONTIN AND KI67 EXPRESSIONS DIFFERENT IN VARIOUS HISTOLOGIC GRADES OF MENINGIOMA? AN IRANIAN EXPERIENCE. IRANIAN JOURNAL OF PATHOLOGY (IJP)[Internet]. 2015;10(4):253-257. Available from: https://sid.ir/paper/665163/en

IEEE: Copy

FOROUGH HASHEMI, PEGAH BABAHEIDARIAN, and SOHEILA DABIRAN, “ARE OSTEOPONTIN AND KI67 EXPRESSIONS DIFFERENT IN VARIOUS HISTOLOGIC GRADES OF MENINGIOMA? AN IRANIAN EXPERIENCE,” IRANIAN JOURNAL OF PATHOLOGY (IJP), vol. 10, no. 4, pp. 253–257, 2015, [Online]. Available: https://sid.ir/paper/665163/en

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