ESTROGEN TREATMENT ENHANCES NEUROGENIC DIFFERENTIATION OF HUMAN ADIPOSE DERIVED STEM CELLSIN VITRO

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

RAZAVI SHAHNAZ; RAZAVI MOHAMMAD REZA; AHMADI NAFISEH; KAZEMI MOHAMMAD

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2015 | Volume:18 | Issue:8 Page(s): 799-804

Download Full-Text

View:

267

Download:

222

Cites:

Information Journal Paper

Title

ESTROGEN TREATMENT ENHANCES NEUROGENIC DIFFERENTIATION OF HUMAN ADIPOSE DERIVED STEM CELLSIN VITRO

Author(s)

RAZAVI SHAHNAZ | RAZAVI MOHAMMAD REZA | AHMADI NAFISEH | KAZEMI MOHAMMAD | Issue Writer Certificate

Keywords

ADIPOSE DERIVED STEM CELLS CELL PROLIFERATION NEUROGENIC DIFFERENTIATION 17β‐ESTRADIOL

Abstract

Objective (s): Estrogen is a sexual hormone that has prominent effects on reproductive and nonreproductive tissues. The aim of this study is to evaluate the effects of estrogen on the proliferation and neural differentiation of human adipose derived stem cells (ADSCs) during neurogenic differentiation.Materials and Methods: Isolated human ADSCs were trans‐differentiated in neural induction medium containing neurobasal medium, N2 and B27 with or without 17b‐estradiol (E2) treatment.Proliferation rate and neural differentiation of human ADSCs were assessed using MTT assay, immunostaining and real time RT‐ PCR analysis, respectively.Results: Analysis of data show that estradiol treatment can significantly increase proliferation rate of differentiated cells (P<0.05). Immunocytochemical and real time RT‐PCR analysis revealed that the expression of precursor and mature neuronal markers (nestin and MAP2) was significantly higher in the E2 treated cell cultures when compared to the untreated cell cultures (P<0.05).Conclusion: According to our findings, estrogen can promote proliferation and neuronal differentiation of human ADSCs.

Cites

No record.

References

No record.

Cite

APA: Copy

RAZAVI, SHAHNAZ, RAZAVI, MOHAMMAD REZA, AHMADI, NAFISEH, & KAZEMI, MOHAMMAD. (2015). ESTROGEN TREATMENT ENHANCES NEUROGENIC DIFFERENTIATION OF HUMAN ADIPOSE DERIVED STEM CELLSIN VITRO. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 18(8), 799-804. SID. https://sid.ir/paper/665302/en

Vancouver: Copy

RAZAVI SHAHNAZ, RAZAVI MOHAMMAD REZA, AHMADI NAFISEH, KAZEMI MOHAMMAD. ESTROGEN TREATMENT ENHANCES NEUROGENIC DIFFERENTIATION OF HUMAN ADIPOSE DERIVED STEM CELLSIN VITRO. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2015;18(8):799-804. Available from: https://sid.ir/paper/665302/en

IEEE: Copy

SHAHNAZ RAZAVI, MOHAMMAD REZA RAZAVI, NAFISEH AHMADI, and MOHAMMAD KAZEMI, “ESTROGEN TREATMENT ENHANCES NEUROGENIC DIFFERENTIATION OF HUMAN ADIPOSE DERIVED STEM CELLSIN VITRO,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 18, no. 8, pp. 799–804, 2015, [Online]. Available: https://sid.ir/paper/665302/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops